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Short term serum pharmacokinetics of diammine silver fluoride after oral application

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dc.contributor.author Vasquez, E.
dc.contributor.author Zegarra, G.
dc.contributor.author Chirinos, E.
dc.contributor.author Castillo, J.L.
dc.contributor.author Taves, D.R.
dc.contributor.author Watson, G.E.
dc.contributor.author Dills, R.
dc.contributor.author Mancl, L.L.
dc.contributor.author Milgrom, P.
dc.date.accessioned 2022-01-18T19:34:36Z
dc.date.available 2022-01-18T19:34:36Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11041
dc.description.abstract Background: There is growing interest in the use of diammine silver fluoride (DSF) as a topical agent to treat dentin hypersensitivity and dental caries as gauged by increasing published research from many parts of the world. While DSF has been available in various formulations for many years, most of its pharmacokinetic aspects within the therapeutic concentration range have never been fully characterized.Methods: This preliminary study determined the applied doses (3 teeth treated), maximum serum concentrations, and time to maximum serum concentration for fluoride and silver in 6 adults over 4 h. Fluoride was determined using the indirect diffusion method with a fluoride selective electrode, and silver was determined using inductively coupled plasma-mass spectrometry. The mean amount of DSF solution applied to the 3 teeth was 7.57 mg (6.04 μL).Results: Over the 4 hour observation period, the mean maximum serum concentrations were 1.86 μmol/L for fluoride and 206 nmol/L for silver. These maximums were reached 3.0 h and 2.5 h for fluoride and silver, respectively.Conclusions: Fluoride exposure was below the U.S. Environmental Protection Agency (EPA) oral reference dose. Silver exposure exceeded the EPA oral reference dose for cumulative daily exposure over a lifetime, but for occasional use was well below concentrations associated with toxicity. This preliminary study suggests that serum concentrations of fluoride and silver after topical application of DSF should pose little toxicity risk when used in adults.Clinical trials registration: NCT01664871. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Oral Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject methodology en_US
dc.subject blood en_US
dc.subject drug effect en_US
dc.subject clinical trial en_US
dc.subject Mass Spectrometry en_US
dc.subject Acute pain en_US
dc.subject Dentin Sensitivity en_US
dc.subject fluoride varnish en_US
dc.subject Fluorides en_US
dc.subject Fluorides, Topical en_US
dc.subject Gingiva en_US
dc.subject Medical device en_US
dc.subject mouth mucosa en_US
dc.subject Mouth Mucosa en_US
dc.subject Pharmacology en_US
dc.subject Quaternary Ammonium Compounds en_US
dc.subject Silver en_US
dc.subject silver diamine fluoride en_US
dc.subject Tooth en_US
dc.subject Topical agent en_US
dc.subject Toxicology en_US
dc.title Short term serum pharmacokinetics of diammine silver fluoride after oral application en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/1472-6831-12-60
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1472-6831


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