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Influenza vaccines licensed in the United States in healthy children: A systematic review and network meta-analysis (Protocol)

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dc.contributor.author Prutsky, G.J.
dc.contributor.author Domecq, J.P.
dc.contributor.author Elraiyah, T.
dc.contributor.author Wang, Z.
dc.contributor.author Grohskopf, L.A.
dc.contributor.author Prokop, L.J.
dc.contributor.author Montori, V.M.
dc.contributor.author Murad, M.H.
dc.date.accessioned 2022-01-18T19:34:36Z
dc.date.available 2022-01-18T19:34:36Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11051
dc.description.abstract Background: Influenza is an acute respiratory illness caused by influenza viruses, which occurs in epidemics worldwide every year. Children are an important target for prevention methods, including vaccination. While evidence about the decision on whether to vaccinate healthy children is robust, evidence supporting the decision of which of available vaccines to use remains unclear.This review will summarize the evidence about the efficacy and safety of the available vaccines for seasonal influenza licensed in the United States for use in healthy children.Methods/design: An umbrella systematic review (SR) and network meta-analysis will be conducted of randomized controlled trials (RCTs). We will search for SRs to identify parallel RCTs evaluating inactive and/or live attenuated influenza vaccines licensed in the United States for use in healthy children to prevent influenza. Subsequently, we will update the literature search of the selected SRs to the present time to capture recent controlled studies. To complement the work focused on harms, we will also select observational studies focusing on post marketing retrospective studies. Inclusion will not be limited by language, publication date or publication status. To identify additional candidate studies, we will review the reference lists of the eligible primary studies and narrative reviews; we will query the expert members of the Advisory Committee on Immunization Practices and review references from their previous statement. Additionally, we will review the reports from the Institute of Medicine on the adverse effects of vaccines. Two reviewers will independently determine study eligibility and will extract descriptive, methodological (using the Cochrane risk of bias tool for RCTs and the Newcastle-Ottawa scale for observational studies) and efficacy data. When possible, we will conduct meta-analyses and network meta-analyses by combining indirect and direct comparisons.We will evaluate heterogeneity using the I2 statistic and the agreement of indirect comparisons and direct evidence. We will report the Cochrane Q test to determine the statistical significance of heterogeneity.The overall quality of evidence will be assessed following the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) approach.Discussion: Our systematic review will allow patients, clinicians, guideline developers and policy makers to make evidence-based choices between the two available vaccine options, by providing information regarding benefits and harms of these types of vaccines. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Systematic Reviews
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Child en_US
dc.subject Humans en_US
dc.subject polymerase chain reaction en_US
dc.subject drug efficacy en_US
dc.subject mortality en_US
dc.subject methodology en_US
dc.subject United States en_US
dc.subject follow up en_US
dc.subject seasonal variation en_US
dc.subject Research Design en_US
dc.subject hospitalization en_US
dc.subject immunization en_US
dc.subject systematic review en_US
dc.subject drug safety en_US
dc.subject Children en_US
dc.subject respiratory tract disease en_US
dc.subject genetic heterogeneity en_US
dc.subject meta analysis (topic) en_US
dc.subject Review Literature as Topic en_US
dc.subject Systematic review en_US
dc.subject Influenza en_US
dc.subject Influenza Vaccines en_US
dc.subject licence en_US
dc.subject Meta-Analysis as Topic en_US
dc.subject Guillain Barre syndrome en_US
dc.subject literature en_US
dc.title Influenza vaccines licensed in the United States in healthy children: A systematic review and network meta-analysis (Protocol) en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1186/2046-4053-1-65
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 2046-4053


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