Universidad Peruana Cayetano Heredia

Impact of international laboratory partnerships on the performance of HIV/sexually transmitted infection testing in five resource-constrained countries

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dc.contributor.author Gaydos, C.A.
dc.contributor.author Rizzo-Price, P.A.
dc.contributor.author Balakrishnan, P.
dc.contributor.author Mateta, P.
dc.contributor.author León Sandoval, Segundo Ramos
dc.contributor.author Verevochkin, S.
dc.contributor.author Yin, Y.P.
dc.contributor.author Quinn, T.C.
dc.contributor.author Strader, L.C.
dc.contributor.author Pequegnat, W.
dc.date.accessioned 2022-01-18T19:34:36Z
dc.date.available 2022-01-18T19:34:36Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11055
dc.description.abstract To review a quality control and quality assurance (QC/QA) model established to ensure the validity and reliability of collection, storage and analysis of biological outcome data, and to promote good laboratory practices (GLPs) and sustained operational improvements in international clinical laboratories, we conducted a two-arm randomized community-level HIV behavioural intervention trial in five countries: China, India, Peru, Russia and Zimbabwe. The trial was based on diffusion theory utilizing a Community Popular Opinion Leaders (CPOLs) intervention model with behavioural and biological outcomes. The QC/QA model was established by the Biological Outcome Workgroup, which collaborated with the Data Coordinating Center and John Hopkins University Reference Laboratory. Five international laboratories conducted chlamydia/gonorrhoea polymerase chain reaction (PRC)-based assays, herpes simplex virus type 2 enzyme immunoassay (EIA), syphilis serology (rapid plasma regain and Treponema pallidum particle agglutination assay, HIV serology (EIA/Western blot) and Trichomonas vaginalis culture. Data were collected at baseline, 12 and 24 months. Laboratory performance and infrastructure improved throughout the trial. Recommendations for improvement were consistently followed. Quality laboratories in resource-poor settings can be established, operating standards can be improved and certification can be obtained with consistent training, monitoring and technical support. Building collaborative partnership relations can establish a sustainable network for clinical trials, and can lead to accreditation and international laboratory development. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries International Journal of STD and AIDS
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject polymerase chain reaction en_US
dc.subject International Cooperation en_US
dc.subject randomized controlled trial (topic) en_US
dc.subject China en_US
dc.subject Human immunodeficiency virus infection en_US
dc.subject Sexually Transmitted Diseases en_US
dc.subject HIV en_US
dc.subject STI en_US
dc.subject syphilis en_US
dc.subject Western blotting en_US
dc.subject Diagnosis en_US
dc.subject bacterium culture en_US
dc.subject Quality Control en_US
dc.subject Developing Countries en_US
dc.subject laboratory en_US
dc.subject enzyme immunoassay en_US
dc.subject clinical laboratory en_US
dc.subject Treponema pallidum en_US
dc.subject reliability en_US
dc.subject gonorrhea en_US
dc.subject India en_US
dc.subject Clinical Laboratory Techniques en_US
dc.subject accreditation en_US
dc.subject Behavior Therapy en_US
dc.subject Biological markers of sexual behavior en_US
dc.subject Capacity building en_US
dc.subject certification en_US
dc.subject Chlamydia en_US
dc.subject good laboratory practice en_US
dc.subject Herpes simplex virus 2 en_US
dc.subject Laboratory testing en_US
dc.subject monitoring en_US
dc.subject Resource-poor settings en_US
dc.subject Russian Federation en_US
dc.subject STD en_US
dc.subject Training partnerships en_US
dc.subject Trichomonas vaginalis en_US
dc.subject validity en_US
dc.subject Zimbabwe en_US
dc.title Impact of international laboratory partnerships on the performance of HIV/sexually transmitted infection testing in five resource-constrained countries en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1258/ijsa.2011.010527
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1758-1052


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