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Development of a panel of genome-wide ancestry informative markers to study admixture throughout the americas

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dc.contributor.author Galanter, J.M.
dc.contributor.author Fernandez-Lopez, J.C.
dc.contributor.author Gignoux, C.R.
dc.contributor.author Barnholtz-Sloan, J.
dc.contributor.author Fernandez-Rozadilla, C.
dc.contributor.author Via, M.
dc.contributor.author Hidalgo-Miranda, A.
dc.contributor.author Contreras, A.V.
dc.contributor.author Figueroa, L.U.
dc.contributor.author Raska, P.
dc.contributor.author Jimenez-Sanchez, G.
dc.contributor.author Zolezzi, I.S.
dc.contributor.author Torres, M.
dc.contributor.author Ponte, C.R.
dc.contributor.author Ruiz, Y.
dc.contributor.author Salas, A.
dc.contributor.author Nguyen, E.
dc.contributor.author Eng, C.
dc.contributor.author Borjas, L.
dc.contributor.author Zabala, W.
dc.contributor.author Barreto, G.
dc.contributor.author González, F.R.
dc.contributor.author Ibarra, A.
dc.contributor.author Taboada, P.
dc.contributor.author Porras, L.
dc.contributor.author Moreno, F.
dc.contributor.author Bigham, A.
dc.contributor.author Gutierrez, G.
dc.contributor.author Brutsaert, T.
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Moore, L.G.
dc.contributor.author Vargas, E.
dc.contributor.author Cruz, M.
dc.contributor.author Escobedo, J.
dc.contributor.author Rodriguez-Santana, J.
dc.contributor.author Rodriguez-Cintrón, W.
dc.contributor.author Chapela, R.
dc.contributor.author Ford, J.G.
dc.contributor.author Bustamante, C.
dc.contributor.author Seminara, D.
dc.contributor.author Shriver, M.
dc.contributor.author Ziv, E.
dc.contributor.author Burchard, E.G.
dc.contributor.author Haile, R.
dc.contributor.author Parra, E.
dc.contributor.author Carracedo, A.
dc.date.accessioned 2022-01-18T19:34:37Z
dc.date.available 2022-01-18T19:34:37Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11058
dc.description.abstract Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capable of being genotyped on widely available commercial platforms, and applicable throughout the Americas by minimizing within-continent heterogeneity. We then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the AIMs panel to estimates based on genome-wide association study (GWAS) data. The panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (R 2&0.9 for ancestral components with significant between-subject variance). Finally, we genotyped samples from 18 populations from Latin America using the AIMs panel and estimated variability in ancestry within and between these populations. This panel and its reference genotype information will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Genetics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject genetics en_US
dc.subject genotype en_US
dc.subject Latin America en_US
dc.subject South and Central America en_US
dc.subject African American en_US
dc.subject Caucasian en_US
dc.subject American Indian en_US
dc.subject Genome, |genetic association en_US
dc.subject Genetic Markers en_US
dc.subject ethnic group en_US
dc.subject genome analysis en_US
dc.subject genetic heterogeneity en_US
dc.subject ethnicity en_US
dc.subject accuracy en_US
dc.subject Western Hemisphere en_US
dc.subject genetic marker en_US
dc.subject Population Dynamics en_US
dc.subject European en_US
dc.subject human genome en_US
dc.subject African Continental Ancestry Group en_US
dc.subject American Native Continental Ancestry Group en_US
dc.subject ancestry informative markers en_US
dc.subject European American en_US
dc.subject European Continental Ancestry Group en_US
dc.subject Mexican en_US
dc.subject Negro en_US
dc.subject process optimization en_US
dc.subject Puerto Rican en_US
dc.title Development of a panel of genome-wide ancestry informative markers to study admixture throughout the americas en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pgen.1002554
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.02
dc.relation.issn 1553-7404


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