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Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: A 10/66 population-based study

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dc.contributor.author Sosa, A.L.
dc.contributor.author Albanese, E.
dc.contributor.author Stephan, B.C.M.
dc.contributor.author Dewey, M.
dc.contributor.author Acosta, D.
dc.contributor.author Ferri, C.P.
dc.contributor.author Guerra, Milagros
dc.contributor.author Huang, Y.
dc.contributor.author Jacob, K.S.
dc.contributor.author Jiménez-Velázquez, I.Z.
dc.contributor.author Rodriguez, J.J.
dc.contributor.author Salas, A.
dc.contributor.author Williams, J.
dc.contributor.author Acosta, I.
dc.contributor.author González-Viruet, M.
dc.contributor.author Guerra Hernandez, M.A.
dc.contributor.author Shuran, L.
dc.contributor.author Prince, M.J.
dc.contributor.author Stewart, R.
dc.date.accessioned 2022-01-18T19:34:37Z
dc.date.available 2022-01-18T19:34:37Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11062
dc.description.abstract Background: Rapid demographic ageing is a growing public health issue in many low- and middle-income countries (LAMICs). Mild cognitive impairment (MCI) is a construct frequently used to define groups of people who may be at risk of developing dementia, crucial for targeting preventative interventions. However, little is known about the prevalence or impact of MCI in LAMIC settings. Methods and Findings: Data were analysed from cross-sectional surveys established by the 10/66 Dementia Research Group and carried out in Cuba, Dominican Republic, Peru, Mexico, Venezuela, Puerto Rico, China, and India on 15,376 individuals aged 65+ without dementia. Standardised assessments of mental and physical health, and cognitive function were carried out including informant interviews. An algorithm was developed to define Mayo Clinic amnestic MCI (aMCI). Disability (12-item World Health Organization disability assessment schedule [WHODAS]) and informant-reported neuropsychiatric symptoms (neuropsychiatric inventory [NPI-Q]) were measured. After adjustment, aMCI was associated with disability, anxiety, apathy, and irritability (but not depression); between-country heterogeneity in these associations was only significant for disability. The crude prevalence of aMCI ranged from 0.8% in China to 4.3% in India. Country differences changed little (range 0.6%-4.6%) after standardization for age, gender, and education level. In pooled estimates, aMCI was modestly associated with male gender and fewer assets but was not associated with age or education. There was no significant between-country variation in these demographic associations. Conclusions: An algorithm-derived diagnosis of aMCI showed few sociodemographic associations but was consistently associated with higher disability and neuropsychiatric symptoms in addition to showing substantial variation in prevalence across LAMIC populations. Longitudinal data are needed to confirm findings-in particular, to investigate the predictive validity of aMCI in these settings and risk/protective factors for progression to dementia; however, the large number affected has important implications in these rapidly ageing settings. Please see later in the article for the Editors' Summary. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Risk Factors en_US
dc.subject Cross-Sectional Studies en_US
dc.subject major clinical study en_US
dc.subject disease association en_US
dc.subject Prevalence en_US
dc.subject sex difference en_US
dc.subject Latin America en_US
dc.subject South and Central America en_US
dc.subject mental disease en_US
dc.subject prevalence en_US
dc.subject China en_US
dc.subject Sex Factors en_US
dc.subject Algorithms en_US
dc.subject hospitalization en_US
dc.subject Severity of Illness Index en_US
dc.subject Developing Countries en_US
dc.subject Mexico en_US
dc.subject Dominican Republic en_US
dc.subject Puerto Rico en_US
dc.subject Venezuela en_US
dc.subject Anxiety en_US
dc.subject Dementia en_US
dc.subject India en_US
dc.subject daily life activity en_US
dc.subject Mental Disorders en_US
dc.subject Social Class en_US
dc.subject Cognition Disorders en_US
dc.subject cognitive defect en_US
dc.subject Disabled Persons en_US
dc.subject Activities of Daily Living en_US
dc.subject physical disability en_US
dc.subject Aging en_US
dc.subject neuropsychological test en_US
dc.subject neurologic examination en_US
dc.subject apathy en_US
dc.subject disabled person en_US
dc.subject irritability en_US
dc.subject mild cognitive impairment en_US
dc.subject Neuropsychological Tests en_US
dc.title Prevalence, distribution, and impact of mild cognitive impairment in Latin America, China, and India: A 10/66 population-based study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pmed.1001170
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1549-1676


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