Universidad Peruana Cayetano Heredia

A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru

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dc.contributor.author Delgado, S.
dc.contributor.author Neyra, R.C.
dc.contributor.author Machaca, V.R.Q.
dc.contributor.author Juárez, J.A.
dc.contributor.author Chu, L.C.
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Apaza, G.M.M.
dc.contributor.author Bocángel, C.D.
dc.contributor.author Tustin, A.W.
dc.contributor.author Sterling, C.R.
dc.contributor.author Comrie, A.C.
dc.contributor.author Naquira Velarde, Cesar Gabriel
dc.contributor.author del Carpio, J.G.C.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Bern, C.
dc.contributor.author Levy, M.Z.
dc.date.accessioned 2022-01-18T19:34:37Z
dc.date.available 2022-01-18T19:34:37Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11066
dc.description.abstract Background:The history of Chagas disease control in Peru and many other nations is marked by scattered and poorly documented vector control campaigns. The complexities of human migration and sporadic control campaigns complicate evaluation of the burden of Chagas disease and dynamics of Trypanosoma cruzi transmission.Methodology/Principal Findings:We conducted a cross-sectional serological and entomological study to evaluate temporal and spatial patterns of T. cruzi transmission in a peri-rural region of La Joya, Peru. We use a multivariate catalytic model and Bayesian methods to estimate incidence of infection over time and thereby elucidate the complex history of transmission in the area. Of 1,333 study participants, 101 (7.6%; 95% CI: 6.2-9.0%) were confirmed T. cruzi seropositive. Spatial clustering of parasitic infection was found in vector insects, but not in human cases. Expanded catalytic models suggest that transmission was interrupted in the study area in 1996 (95% credible interval: 1991-2000), with a resultant decline in the average annual incidence of infection from 0.9% (95% credible interval: 0.6-1.3%) to 0.1% (95% credible interval: 0.005-0.3%). Through a search of archival newspaper reports, we uncovered documentation of a 1995 vector control campaign, and thereby independently validated the model estimates.Conclusions/Significance:High levels of T. cruzi transmission had been ongoing in peri-rural La Joya prior to interruption of parasite transmission through a little-documented vector control campaign in 1995. Despite the efficacy of the 1995 control campaign, T. cruzi was rapidly reemerging in vector populations in La Joya, emphasizing the need for continuing surveillance and control at the rural-urban interface. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject controlled study en_US
dc.subject Cross-Sectional Studies en_US
dc.subject major clinical study en_US
dc.subject cluster analysis en_US
dc.subject Communicable Disease Control en_US
dc.subject disease carrier en_US
dc.subject disease transmission en_US
dc.subject epidemiology en_US
dc.subject rural area en_US
dc.subject vector control en_US
dc.subject school child en_US
dc.subject incidence en_US
dc.subject methodology en_US
dc.subject blood en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject Rural Population en_US
dc.subject Chagas Disease en_US
dc.subject Trypanosoma cruzi en_US
dc.subject Time Factors en_US
dc.subject infection control en_US
dc.subject immunology en_US
dc.subject Recurrence en_US
dc.subject Antibodies, Protozoan en_US
dc.subject serology en_US
dc.subject recurrent disease en_US
dc.subject Topography, Medical en_US
dc.subject protozoon antibody en_US
dc.subject history en_US
dc.subject Insect Control en_US
dc.subject History, 20th Century en_US
dc.subject parasitosis en_US
dc.subject History, 21st Century en_US
dc.subject zoology en_US
dc.title A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0000970
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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