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Multi-locus sequence analysis reveals profound genetic diversity among isolates of the human pathogen bartonella bacilliformis

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dc.contributor.author Chaloner, G.L.
dc.contributor.author Ventosilla, P.
dc.contributor.author Birtles, R.J.
dc.date.accessioned 2022-01-18T19:34:37Z
dc.date.available 2022-01-18T19:34:37Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11069
dc.description.abstract Bartonella bacilliformis is the aetiological agent of human bartonellosis, a potentially life threatening infection of significant public health concern in the Andean region of South America. Human bartonellosis has long been recognised in the region but a recent upsurge in the number of cases of the disease and an apparent expansion of its geographical distribution have re-emphasized its contemporary medical importance. Here, we describe the development of a multi-locus sequence typing (MLST) scheme for B. bacilliformis and its application to an archive of 43 isolates collected from patients across Peru. MLST identified eight sequence types among these isolates and the delineation of these was generally congruent with those of the previously described typing scheme. Phylogenetic analysis based on concatenated sequence data derived from MLST loci revealed that seven of the eight sequence types were closely related to one another; however, one sequence type, ST8, exhibited profound evolutionary divergence from the others. The extent of this divergence was akin to that observed between other members of the Bartonella genus, suggesting that ST8 strains may be better considered as members of a novel Bartonella genospecies. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject controlled study en_US
dc.subject isolation and purification en_US
dc.subject microbiology en_US
dc.subject genetics en_US
dc.subject non nucleotide sequence en_US
dc.subject phylogeny en_US
dc.subject Infant en_US
dc.subject Retrospective Studies en_US
dc.subject methodology en_US
dc.subject Cluster Analysis en_US
dc.subject molecular phylogeny en_US
dc.subject population structure en_US
dc.subject DNA, Bacterial en_US
dc.subject sequence homology en_US
dc.subject Bartonella bacilliformis en_US
dc.subject Bartonella Infections en_US
dc.subject bartonellosis en_US
dc.subject Molecular Epidemiology en_US
dc.subject gene locus en_US
dc.subject bacterium isolate en_US
dc.subject genetic variability en_US
dc.subject bacterial strain en_US
dc.subject retrospective study en_US
dc.subject Phylogeny en_US
dc.subject Multilocus Sequence Typing en_US
dc.title Multi-locus sequence analysis reveals profound genetic diversity among isolates of the human pathogen bartonella bacilliformis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001248
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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