Universidad Peruana Cayetano Heredia

Cognitive changes and quality of life in neurocysticercosis: A longitudinal study

Mostrar el registro sencillo del ítem

dc.contributor.author Wallin, M.T.
dc.contributor.author Pretell, E.J.
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Caballero, M.
dc.contributor.author Alfaro, M.
dc.contributor.author Kane, R.
dc.contributor.author Wilken, J.
dc.contributor.author Sullivan, C.
dc.contributor.author Fratto, T.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2022-01-18T19:34:37Z
dc.date.available 2022-01-18T19:34:37Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11072
dc.description.abstract Background: Few studies have focused on the cognitive morbidity of neurocysticercosis (NCC), one of the most common parasitic infections of the central nervous system. We longitudinally assessed the cognitive status and quality of life (QoL) of patients with incident symptomatic NCC cases and matched controls. Methodology/Principal Findings: The setting of the study was the Sabogal Hospital and Cysticercosis Unit, Department of Transmissible Diseases, National Institute of Neurological Sciences, Lima, Peru. The design was a longitudinal study of new onset NCC cases and controls. Participants included a total of 14 patients with recently diagnosed NCC along with 14 healthy neighborhood controls and 7 recently diagnosed epilepsy controls. A standardized neuropsychological battery was performed at baseline and at 6 months on NCC cases and controls. A brain MRI was performed in patients with NCC at baseline and 6 months. Neuropsychological results were compared between NCC cases and controls at both time points. At baseline, patients with NCC had lower scores on attention tasks (p<0.04) compared with epilepsy controls but no significant differences compared to healthy controls. Six months after receiving anti-parasitic treatment, the NCC group significantly improved on tasks involving psychomotor speed (p<0.02). QoL at baseline suggested impaired mental function and social function in both the NCC and epilepsy group compared with healthy controls. QoL gains in social function (p = 0.006) were noted at 6 months in patients with NCC. Conclusions/Significance: Newly diagnosed patients with NCC in this sample had mild cognitive deficits and more marked decreases in quality of life at baseline compared with controls. Improvements were found in both cognitive status and quality of life in patients with NCC after treatment. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Case-Control Studies en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject nuclear magnetic resonance imaging en_US
dc.subject psychological aspect en_US
dc.subject follow up en_US
dc.subject clinical article en_US
dc.subject learning en_US
dc.subject antiparasitic agent en_US
dc.subject Longitudinal Studies en_US
dc.subject albendazole en_US
dc.subject Brain en_US
dc.subject social status en_US
dc.subject radiography en_US
dc.subject Quality of Life en_US
dc.subject Neurocysticercosis en_US
dc.subject problem solving en_US
dc.subject carbamazepine en_US
dc.subject phenytoin en_US
dc.subject brain en_US
dc.subject focal epilepsy en_US
dc.subject anticonvulsive agent en_US
dc.subject mental function en_US
dc.subject Cognition Disorders en_US
dc.subject cognitive defect en_US
dc.subject Neuropsychological Tests en_US
dc.subject affect en_US
dc.subject alertness en_US
dc.subject attention en_US
dc.subject clonazepam en_US
dc.subject generalized epilepsy en_US
dc.subject psychomotor performance en_US
dc.subject recall en_US
dc.subject Short Form 36 en_US
dc.subject valproic acid en_US
dc.title Cognitive changes and quality of life in neurocysticercosis: A longitudinal study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001493
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas