Universidad Peruana Cayetano Heredia

A research agenda for helminth diseases of humans: Towards control and elimination

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dc.contributor.author Boatin, B.A.
dc.contributor.author Basáñez, M.-G.
dc.contributor.author Prichard, R.K.
dc.contributor.author Awadzi, K.
dc.contributor.author Barakat, R.M.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Gazzinelli, A.
dc.contributor.author Grant, W.N.
dc.contributor.author McCarthy, J.S.
dc.contributor.author N'Goran, E.K.
dc.contributor.author Osei-Atweneboana, M.Y.
dc.contributor.author Sripa, B.
dc.contributor.author Yang, G.-J.
dc.contributor.author Lustigman, S.
dc.date.accessioned 2022-01-18T19:34:37Z
dc.date.available 2022-01-18T19:34:37Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11073
dc.description.abstract Human helminthiases are of considerable public health importance in sub-Saharan Africa, Asia, and Latin America. The acknowledgement of the disease burden due to helminth infections, the availability of donated or affordable drugs that are mostly safe and moderately efficacious, and the implementation of viable mass drug administration (MDA) interventions have prompted the establishment of various large-scale control and elimination programmes. These programmes have benefited from improved epidemiological mapping of the infections, better understanding of the scope and limitations of currently available diagnostics and of the relationship between infection and morbidity, feasibility of community-directed or school-based interventions, and advances in the design of monitoring and evaluation (M&E) protocols. Considerable success has been achieved in reducing morbidity or suppressing transmission in a number of settings, whilst challenges remain in many others. Some of the obstacles include the lack of diagnostic tools appropriate to the changing requirements of ongoing interventions and elimination settings; the reliance on a handful of drugs about which not enough is known regarding modes of action, modes of resistance, and optimal dosage singly or in combination; the difficulties in sustaining adequate coverage and compliance in prolonged and/or integrated programmes; an incomplete understanding of the social, behavioural, and environmental determinants of infection; and last, but not least, very little investment in research and development (R&D). The Disease Reference Group on Helminth Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), was given the mandate to undertake a comprehensive review of recent advances in helminthiases research, identify research gaps, and rank priorities for an R&D agenda for the control and elimination of these infections. This review presents the processes undertaken to identify and rank ten top research priorities; discusses the implications of realising these priorities in terms of their potential for improving global health and achieving the Millennium Development Goals (MDGs); outlines salient research funding needs; and introduces the series of reviews that follow in this PLoS Neglected Tropical Diseases collection, "A Research Agenda for Helminth Diseases of Humans.". en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject clinical evaluation en_US
dc.subject health en_US
dc.subject parasitology en_US
dc.subject Communicable Disease Control en_US
dc.subject disease control en_US
dc.subject medical research en_US
dc.subject parasite transmission en_US
dc.subject morbidity en_US
dc.subject Disease Eradication en_US
dc.subject funding en_US
dc.subject health program en_US
dc.subject Latin America en_US
dc.subject South and Central America en_US
dc.subject review en_US
dc.subject methodology en_US
dc.subject infection control en_US
dc.subject albendazole en_US
dc.subject economics en_US
dc.subject disease surveillance en_US
dc.subject praziquantel en_US
dc.subject ivermectin en_US
dc.subject World Health en_US
dc.subject Helminthiasis en_US
dc.subject Biomedical Research en_US
dc.subject organization and management en_US
dc.subject Parasitology en_US
dc.subject antibiotic agent en_US
dc.subject drug development en_US
dc.subject mebendazole en_US
dc.subject quality adjusted life year en_US
dc.subject parasite control en_US
dc.subject Asia en_US
dc.subject tropical disease en_US
dc.subject monitoring en_US
dc.subject Africa south of the Sahara en_US
dc.subject Africa South of the Sahara en_US
dc.subject diethylcarbamazine en_US
dc.subject drug research en_US
dc.subject ecology en_US
dc.title A research agenda for helminth diseases of humans: Towards control and elimination en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001547
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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