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A research agenda for helminth diseases of humans: Diagnostics for control and elimination programmes

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dc.contributor.author McCarthy, J.S.
dc.contributor.author Lustigman, S.
dc.contributor.author Yang, G.-J.
dc.contributor.author Barakat, R.M.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Sripa, B.
dc.contributor.author Willingham, A.L.
dc.contributor.author Prichard, R.K.
dc.contributor.author Basáñez, M.-G.
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11075
dc.description.abstract Diagnostic tools appropriate for undertaking interventions to control helminth infections are key to their success. Many diagnostic tests for helminth infection have unsatisfactory performance characteristics and are not well suited for use in the parasite control programmes that are being increasingly implemented. Although the application of modern laboratory research techniques to improve diagnostics for helminth infection has resulted in some technical advances, uptake has not been uniform. Frequently, pilot or proof of concept studies of promising diagnostic technologies have not been followed by much needed product development, and in many settings diagnosis continues to rely on insensitive and unsatisfactory parasitological or serodiagnostic techniques. In contrast, PCR-based xenomonitoring of arthropod vectors, and use of parasite recombinant proteins as reagents for serodiagnostic tests, have resulted in critical advances in the control of specific helminth parasites. The Disease Reference Group on Helminths Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR) was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, the diagnostic technologies relevant to control of helminth infections, either available or in development, are reviewed. Critical gaps are identified and opportunities to improve needed technologies are discussed. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject non parasitology en_US
dc.subject polymerase chain reaction en_US
dc.subject Communicable Disease Control en_US
dc.subject disease severity en_US
dc.subject health program en_US
dc.subject review en_US
dc.subject drug efficacy en_US
dc.subject methodology en_US
dc.subject infection control en_US
dc.subject parasite identification en_US
dc.subject sensitivity and specificity en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject taeniasis en_US
dc.subject cysticercosis en_US
dc.subject praziquantel en_US
dc.subject feces analysis en_US
dc.subject diagnostic procedure en_US
dc.subject antibody detection en_US
dc.subject Helminthiasis en_US
dc.subject drug monitoring en_US
dc.subject antigen detection en_US
dc.subject Clinical Laboratory Techniques en_US
dc.subject Drug Monitoring en_US
dc.subject Parasitology en_US
dc.subject anthelmintic agent en_US
dc.subject parasite control en_US
dc.subject schistosomiasis en_US
dc.subject chemotherapy en_US
dc.subject lymphatic filariasis en_US
dc.subject cystic hydatid disease en_US
dc.subject food borne trematodiasis en_US
dc.subject onchocerciasis en_US
dc.subject soil transmitted helminthiasis en_US
dc.subject worm infection en_US
dc.title A research agenda for helminth diseases of humans: Diagnostics for control and elimination programmes en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001601
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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