Universidad Peruana Cayetano Heredia

Correlation of serotype-specific dengue virus infection with clinical manifestations

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dc.contributor.author Halsey, E.S.
dc.contributor.author Marks, M.A.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Fiestas, V.
dc.contributor.author Suarez, L.
dc.contributor.author Vargas, J.
dc.contributor.author Aguayo, N.
dc.contributor.author Madrid, C.
dc.contributor.author Vimos, C.
dc.contributor.author Kochel, T.J.
dc.contributor.author Laguna-Torres, V.A.
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11076
dc.description.abstract Background: Disease caused by the dengue virus (DENV) is a significant cause of morbidity throughout the world. Although prior research has focused on the association of specific DENV serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) with the development of severe outcomes such as dengue hemorrhagic fever and dengue shock syndrome, relatively little work has correlated other clinical manifestations with a particular DENV serotype. The goal of this study was to estimate and compare the prevalence of non-hemorrhagic clinical manifestations of DENV infection by serotype. Methodology and Principal Findings: Between the years 2005-, individuals with febrile disease from Peru, Bolivia, Ecuador, and Paraguay were enrolled in an outpatient passive surveillance study. Detailed information regarding clinical signs and symptoms, as well as demographic information, was collected. DENV infection was confirmed in patient sera with polyclonal antibodies in a culture-based immunofluorescence assay, and the infecting serotype was determined by serotype-specific monoclonal antibodies. Differences in the prevalence of individual and organ-system manifestations were compared across DENV serotypes. One thousand seven hundred and sixteen individuals were identified as being infected with DENV-1 (39.8%), DENV-2 (4.3%), DENV-3 (41.5%), or DENV-4 (14.4%). When all four DENV serotypes were compared with each other, individuals infected with DENV-3 had a higher prevalence of musculoskeletal and gastrointestinal manifestations, and individuals infected with DENV-4 had a higher prevalence of respiratory and cutaneous manifestations. Conclusions/Significance: Specific clinical manifestations, as well as groups of clinical manifestations, are often overrepresented by an individual DENV serotype. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject cross-sectional study en_US
dc.subject isolation and purification en_US
dc.subject major clinical study en_US
dc.subject pathology en_US
dc.subject classification en_US
dc.subject pathogenicity en_US
dc.subject polymerase chain reaction en_US
dc.subject South America en_US
dc.subject gastrointestinal disease en_US
dc.subject neurologic disease en_US
dc.subject prevalence en_US
dc.subject virology en_US
dc.subject disease surveillance en_US
dc.subject immunoglobulin G en_US
dc.subject immunoglobulin M en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject Serotyping en_US
dc.subject Dengue en_US
dc.subject serotype en_US
dc.subject respiratory tract disease en_US
dc.subject immunofluorescence test en_US
dc.subject musculoskeletal disease en_US
dc.subject Dengue Virus en_US
dc.subject Dengue virus 1 en_US
dc.subject Dengue virus 2 en_US
dc.subject Dengue virus 3 en_US
dc.subject Dengue virus 4 en_US
dc.subject skin manifestation en_US
dc.title Correlation of serotype-specific dengue virus infection with clinical manifestations en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001638
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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