Universidad Peruana Cayetano Heredia

Bartonella bacilliformis: A Systematic Review of the Literature to Guide the Research Agenda for Elimination

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dc.contributor.author Sanchez Clemente, N.
dc.contributor.author Ugarte Gil, Cesar Augusto
dc.contributor.author Solórzano, N.
dc.contributor.author Maguiña Vargas, Ciro
dc.contributor.author Pachas, P.
dc.contributor.author Blazes, D.
dc.contributor.author Bailey, R.
dc.contributor.author Mabey, D.
dc.contributor.author Moore, David Alexander James
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11081
dc.description.abstract Background: Carrion's disease affects small Andean communities in Peru, Colombia and Ecuador and is characterized by two distinct disease manifestations: an abrupt acute bacteraemic illness (Oroya fever) and an indolent cutaneous eruptive condition (verruga Peruana). Case fatality rates of untreated acute disease can exceed 80% during outbreaks. Despite being an ancient disease that has affected populations since pre-Inca times, research in this area has been limited and diagnostic and treatment guidelines are based on very low evidence reports. The apparently limited geographical distribution and ecology of Bartonella bacilliformis may present an opportunity for disease elimination if a clear understanding of the epidemiology and optimal case and outbreak management can be gained. Methods: All available databases were searched for English and Spanish language articles on Carrion's disease. In addition, experts in the field were consulted for recent un-published work and conference papers. The highest level evidence studies in the fields of diagnostics, treatment, vector control and epidemiology were critically reviewed and allocated a level of evidence, using the Oxford Centre for Evidence-Based Medicine (CEBM) guidelines. Results: A total of 44 studies were considered to be of sufficient quality to be included in the analysis. The majority of these were level 4 or 5 (low quality) evidence and based on small sample sizes. Few studies had been carried out in endemic areas. Conclusions: Current approaches to the diagnosis and management of Carrion's disease are based on small retrospective or observational studies and expert opinion. Few studies take a public health perspective or examine vector control and prevention. High quality studies performed in endemic areas are required to define optimal diagnostic and treatment strategies. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject polymerase chain reaction en_US
dc.subject asymptomatic infection en_US
dc.subject geographic distribution en_US
dc.subject vector control en_US
dc.subject Colombia en_US
dc.subject Disease Eradication en_US
dc.subject rifampicin en_US
dc.subject Western blotting en_US
dc.subject sensitivity and specificity en_US
dc.subject streptomycin en_US
dc.subject blood smear en_US
dc.subject Bartonella bacilliformis en_US
dc.subject Bartonella Infections en_US
dc.subject Carrion disease en_US
dc.subject immunization en_US
dc.subject systematic review en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject ciprofloxacin en_US
dc.subject predictive value en_US
dc.subject azithromycin en_US
dc.subject chloramphenicol en_US
dc.subject clinical trial (topic) en_US
dc.subject zoonosis en_US
dc.subject Ecuador en_US
dc.subject sultamicillin en_US
dc.subject Insect Control en_US
dc.subject blood transfusion en_US
dc.subject immunoblotting en_US
dc.subject incubation time en_US
dc.subject deflazacort en_US
dc.subject fluorescent antibody technique en_US
dc.title Bartonella bacilliformis: A Systematic Review of the Literature to Guide the Research Agenda for Elimination en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001819
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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