Universidad Peruana Cayetano Heredia

Geographic Correlation between Tapeworm Carriers and Heavily Infected Cysticercotic Pigs

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dc.contributor.author O'Neal, Seth E.
dc.contributor.author Moyano, L.M.
dc.contributor.author Ayvar, V.
dc.contributor.author Gonzalvez, G.
dc.contributor.author Diaz, A.
dc.contributor.author Rodriguez, S.
dc.contributor.author Wilkins, P.P.
dc.contributor.author Tsang, V.C.W.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11083
dc.description.abstract Background: Neurocysticercosis is a leading cause of preventable epilepsy in the developing world. Sustainable community-based interventions are urgently needed to control transmission of the causative parasite, Taenia solium. We examined the geospatial relationship between live pigs with visible cysticercotic cysts on their tongues and humans with adult intestinal tapeworm infection (taeniasis) in a rural village in northern Peru. The objective was to determine whether tongue-positive pigs could indicate high-risk geographic foci for taeniasis to guide targeted screening efforts. This approach could offer significant benefit compared to mass intervention. Methods: We recorded geographic coordinates of all village houses, collected stool samples from all consenting villagers, and collected blood and examined tongues of all village pigs. Stool samples were processed by enzyme-linked immunosorbent assay (ELISA) for presence of Taenia sp. coproantigens indicative of active taeniasis; serum was processed by enzyme-linked immunoelectrotransfer blot for antibodies against T. solium cysticercosis (EITB LLGP) and T. solium taeniasis (EITB rES33). Findings: Of 548 pigs, 256 (46.7%) were positive for antibodies against cysticercosis on EITB LLGP. Of 402 fecal samples, 6 (1.5%) were positive for the presence of Taenia sp. coproantigens. The proportion of coproantigen-positive individuals differed significantly between residents living within 100-meters of a tongue-positive pig (4/79, 5.1%) and residents living >100 meters from a tongue-positive pig (2/323, 0.6%) (p = 0.02). The prevalence of taeniasis was >8 times higher among residents living within 100 meters of a tongue-positive pig compared to residents living outside this range (adjusted PR 8.1, 95% CI 1.4-47.0). Conclusions: Tongue-positive pigs in endemic communities can indicate geospatial foci in which the risk for taeniasis is increased. Targeted screening or presumptive treatment for taeniasis within these high-risk foci may be an effective and practical control intervention for rural endemic areas. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Animals en_US
dc.subject non disease carrier en_US
dc.subject disease association en_US
dc.subject prevalence en_US
dc.subject Rural Population en_US
dc.subject Feces en_US
dc.subject household en_US
dc.subject infection risk en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject Taenia solium en_US
dc.subject Swine en_US
dc.subject Swine Diseases en_US
dc.subject feces analysis en_US
dc.subject microscopy en_US
dc.subject neurocysticercosis en_US
dc.subject Topography, Medical en_US
dc.subject Antibodies, Helminth en_US
dc.subject immunoblotting en_US
dc.subject Tongue en_US
dc.subject Cestode Infections en_US
dc.title Geographic Correlation between Tapeworm Carriers and Heavily Infected Cysticercotic Pigs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0001953
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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