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A1c as a diagnostic criteria for diabetes in low- and middle-income settings: Evidence from PERU

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dc.contributor.author Miranda, J. Jaime
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Stanojevic, S.
dc.contributor.author Málaga Rodríguez, Germán Javier
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Smeeth, L.
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11086
dc.description.abstract Objectives: To determine the prevalence of type 2 diabetes mellitus, in three groups of Peruvian adults, using fasting glucose and glycosylated hemoglobin (A1C). Methodology/Principal Findings: This study included adults from the PERU MIGRANT Study who had fasted ≥8 h. Fasting glucose ≥126 mg/dL and A1C≥6.5% were used, separately, to define diabetes. Subjects with a current diagnosis of diabetes were excluded. 964 of 988 subjects were included in this analysis. Overall, 0.9% (95%CI 0.3-1.5) and 3.5% (95%CI 2.4-4.7) had diabetes using fasting glucose and A1C criteria, respectively. Compared to those classified as having diabetes using fasting glucose, newly classified subjects with diabetes using A1C (n = 25), were older, poorer, thinner and more likely to come from rural areas. Of these, 40% (10/25) had impaired fasting glucose (IFG). Conclusions: This study shows that the use of A1C as diagnostic criteria for type 2 diabetes mellitus identifies people of different characteristics than fasting glucose. In the PERU MIGRANT population using A1C to define diabetes tripled the prevalence; the increase was more marked among poorer and rural populations. More than half the newly diagnosed people with diabetes using A1C had normal fasting glucose. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject controlled study en_US
dc.subject metabolism en_US
dc.subject prevalence en_US
dc.subject blood en_US
dc.subject clinical article en_US
dc.subject age en_US
dc.subject rural population en_US
dc.subject Income en_US
dc.subject diagnostic value en_US
dc.subject high risk population en_US
dc.subject migration en_US
dc.subject Diabetes Mellitus en_US
dc.subject glucose blood level en_US
dc.subject non insulin dependent diabetes mellitus en_US
dc.subject lowest income group en_US
dc.subject Emigration and Immigration en_US
dc.subject Blood Glucose en_US
dc.subject hemoglobin A1c en_US
dc.subject impaired glucose tolerance en_US
dc.subject diet restriction en_US
dc.subject diagnostic agent en_US
dc.subject glycosylated hemoglobin en_US
dc.subject Hemoglobin A, Glycosylated en_US
dc.subject Fasting en_US
dc.title A1c as a diagnostic criteria for diabetes in low- and middle-income settings: Evidence from PERU en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0018069
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1932-6203

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