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Weight variation over time and its association with tuberculosis treatment outcome: A longitudinal analysis

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dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Sanchez, J.F.
dc.contributor.author Rios, J.
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11088
dc.description.abstract Objective: Weight variation during therapy has been described as a useful marker to predict TB treatment outcome. No previous study has used longitudinal analysis to corroborate this finding. The goal of this study was to evaluate change and trends of patients' bodyweight over time depending on TB treatment outcome. Methods and Findings: A retrospective cohort study with all TB cases diagnosed from 2000 to 2006 was carried out. Information from 5 public tuberculosis treatment facilities at Pampas de San Juan de Miraflores, Lima, Peru was analyzed. Poor outcome was defined as failure or death during TB therapy, and compared to good outcome defined as cured. Longitudinal analysis with a pre-specified marginal model was fitted using Generalized Estimating Equations to compare weight trends for patients with good and poor outcome adjusting for potential confounders. A total of 460 patients (55.4% males, mean age: 31.6 years) were included in the analysis: 42 (9.1%) had a poor outcome (17 failed and 25 died). Weight at baseline was not different comparing outcome groups (p = 0.17). After adjusting for age, gender, type of TB, scheme of treatment, HIV status and sputum variation during follow-up, after the first month of treatment, patients with good outcome gained, on average, almost 1 kg compared to their baseline weight (p<0.001), whereas those with poor outcome lost 1 kg (p = 0.003). Similarly, after 4 months, a patient with good outcome increased 3 kg on average (p<0.001), while those with poor outcome only gained 0.2 kg (p = 0.02). Conclusions: Weight variation during tuberculosis therapy follow-up can predict treatment outcome. Patients losing weight during TB treatment, especially in the first month, should be more closely followed as they are at risk of failure or death. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject cohort analysis en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject physiology en_US
dc.subject Human immunodeficiency virus infection en_US
dc.subject Follow-Up Studies en_US
dc.subject age en_US
dc.subject Treatment Outcome en_US
dc.subject Body Weight en_US
dc.subject weight gain en_US
dc.subject pathophysiology en_US
dc.subject Time Factors en_US
dc.subject Longitudinal Studies en_US
dc.subject Tuberculosis en_US
dc.subject sputum en_US
dc.subject treatment outcome en_US
dc.subject tuberculostatic agent en_US
dc.subject death en_US
dc.subject retrospective study en_US
dc.subject gender en_US
dc.subject Models, Biological en_US
dc.subject weight reduction en_US
dc.subject trend study en_US
dc.subject prediction en_US
dc.subject short course therapy en_US
dc.subject treatment failure en_US
dc.subject high risk patient en_US
dc.subject weight change en_US
dc.title Weight variation over time and its association with tuberculosis treatment outcome: A longitudinal analysis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0018474
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1932-6203

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