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HBV infection in relation to consistent condom use: a population-based study in Peru.

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dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Scott, John D.
dc.contributor.author Hughes, James P.
dc.contributor.author Garcia Funegra, Patricia Jannet
dc.contributor.author Holmes, King K.
dc.date.accessioned 2022-01-18T19:34:38Z
dc.date.available 2022-01-18T19:34:38Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11091
dc.description.abstract Background: Data on hepatitis B virus (HBV) prevalence are limited in developing countries. There is also limited information of consistent condom use efficacy for reducing HBV transmission at the population level. The study goal was to evaluate the prevalence and factors associated with HBV infection in Peru, and the relationship between anti-HBc positivity and consistent condom use. METHODS AND FINDINGS: Data from two different surveys performed in 28 mid-sized Peruvian cities were analyzed. Participants aged 18-29 years were selected using a multistage cluster sampling. Information was collected through a validated two-part questionnaire. The first part (face-to-face) concerned demographic data, while the second part (self-administered using handheld computers) concerned sexual behavior. Hepatitis B core antibody (anti-HBc) was tested in 7,000 blood samples. Prevalences and associations were adjusted for sample strata, primary sampling units and population weights. Anti-HBc prevalence was 5.0% (95%CI 4.1%-5.9%), with the highest prevalence among jungle cities: 16.3% (95%CI 13.8%-19.1%). In the multivariable analysis, Anti-HBc positivity was directly associated with geographic region (highlands OR = 2.05; 95%CI 1.28-3.27, and jungle OR = 4.86; 95%CI 3.05-7.74; compared to coastal region); and inversely associated with age at sexual debut (OR = 0.90; 95%CI 0.85-0.97). Consistent condom use, evaluated in about 40% of participants, was associated with reduced prevalence (OR = 0.34; 95%CI 0.15-0.79) after adjusting for gender, geographic region, education level, lifetime number of sex partners, age at sexual debut and year of survey. CONCLUSION: Residence in highlands or jungle cities is associated with higher anti-HBc prevalences, whereas increasing age at sexual debut were associated with lower prevalences. Consistent condom use was associated with decreased risk of anti-HBc. Findings from this study emphasize the need of primary prevention programs (vaccination) especially in the jungle population, and imply that condom use promotion might be a potential strategy to prevent HBV infection. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject city en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject geographic distribution en_US
dc.subject Prevalence en_US
dc.subject health survey en_US
dc.subject high risk behavior en_US
dc.subject prevalence en_US
dc.subject sexual behavior en_US
dc.subject blood en_US
dc.subject Condoms en_US
dc.subject utilization review en_US
dc.subject educational status en_US
dc.subject age en_US
dc.subject immunology en_US
dc.subject infection rate en_US
dc.subject infection risk en_US
dc.subject gender en_US
dc.subject risk reduction en_US
dc.subject antibody blood level en_US
dc.subject seroprevalence en_US
dc.subject Hepatitis B en_US
dc.subject Hepatitis B Antibodies en_US
dc.subject Hepatitis B virus en_US
dc.subject residential area en_US
dc.title HBV infection in relation to consistent condom use: a population-based study in Peru. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0024721
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1932-6203


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