Universidad Peruana Cayetano Heredia

Does Childhood Diarrhea Influence Cognition Beyond the Diarrhea-Stunting Pathway?

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dc.contributor.author Fischer Walker, C.L.
dc.contributor.author Lamberti, L.
dc.contributor.author Adair, L.
dc.contributor.author Guerrant, R.L.
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.contributor.author Martorell, R.
dc.contributor.author Pinkerton, R.C.
dc.contributor.author Black, R.E.
dc.date.accessioned 2022-01-18T19:34:39Z
dc.date.available 2022-01-18T19:34:39Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11110
dc.description.abstract Background: Diarrhea is a leading cause of morbidity among children under 5 years of age in low- and middle-income countries yet the additional effects and sequelae, such as cognitive impairment associated with diarrhea, have not been quantified. Methods: We quantified the association between diarrhea prevalence and cognitive outcomes while controlling for linear growth in 4 study populations. Cognition was assessed using different methods across sites and was expressed in standardized units. We built linear regression models for each study with standardized cognitive score as the outcome and diarrhea prevalence as the main predictor variable. We then conducted meta-analyses of the regression coefficients to generate pooled estimates of the association between diarrhea prevalence and cognition whilst controlling for anthropometric status and other covariates. Results: Diarrhea was not a significant predictor of cognitive score in any site in the regression models or in the meta-analyses (Coefficient = 0.07; 95% CI: -0.1, 0.2). The length for age Z- score was negatively related to cognition in all sites (0.18; 95% CI: 0.14, 0.21), with coefficients remarkably similar across sites (Coefficient Range: 0.168-0.186). Conclusions: We did not demonstrate an association between diarrhea and cognition with stunting included in the model. The links between diarrhea, stunting, and cognition provide additional rationale for accelerating interventions to reduce diarrhea. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject population research en_US
dc.subject disease association en_US
dc.subject prevalence en_US
dc.subject Linear Models en_US
dc.subject Anthropometry en_US
dc.subject stunting en_US
dc.subject Diarrhea en_US
dc.subject childhood disease en_US
dc.subject scoring system en_US
dc.subject correlation coefficient en_US
dc.subject meta analysis (topic) en_US
dc.subject Cognition Disorders en_US
dc.subject cognitive defect en_US
dc.subject Cognition en_US
dc.subject predictor variable en_US
dc.title Does Childhood Diarrhea Influence Cognition Beyond the Diarrhea-Stunting Pathway? en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0047908
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1932-6203


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