DSpace Repository

Exercise pathophysiology in patients with chronic mountain sickness exercise in chronic mountain sickness.

Show simple item record

dc.contributor.author Groepenhoff, Herman
dc.contributor.author Overbeek, Marieke J.
dc.contributor.author Mulè, Massimiliano
dc.contributor.author van der Plas, Mart
dc.contributor.author Argiento, Paola
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Beloka, Sophia
dc.contributor.author Faoro, Vitalie
dc.contributor.author Macarlupu, Jose L.
dc.contributor.author Guenard, Herve
dc.contributor.author de Bisschop, Claire
dc.contributor.author Martinot, Jean-Benoit
dc.contributor.author Vanderpool, Rebecca
dc.contributor.author Penaloza, Dante
dc.contributor.author Naeije, Robert
dc.date.accessioned 2022-01-18T19:34:40Z
dc.date.available 2022-01-18T19:34:40Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11118
dc.description.abstract Background: Chronic mountain sickness (CMS) is characterized by a combination of excessive erythrocytosis,severe hypoxemia, and pulmonary hypertension, all of which affect exercise capacity. METHODS: Thirteen patients with CMS and 15 healthy highlander and 15 newcomer lowlander control subjects were investigated at an altitude of 4,350 m (Cerro de Pasco, Peru). All of them underwent measurements of diffusing capacity of lung for nitric oxide and carbon monoxide at rest, echocardiography for estimation of mean pulmonary arterial pressure and cardiac output at rest and at exercise, and an incremental cycle ergometer cardiopulmonary exercise test. RESULTS: The patients with CMS, the healthy highlanders, and the newcomer lowlanders reached a similar maximal oxygen uptake at 32 1, 32 2, and 33 2 mL/min/kg, respectively, mean SE( P 5 .8), with ventilatory equivalents for C O 2 vs end-tidal P CO 2 , measured at the anaerobic threshold,of 0.9 0.1, 1.2 0.1, and 1.4 0.1 mm Hg, respectively ( P , .001); arterial oxygen content of 26 1, 21 2, and 16 1 mL/dL, respectively ( P , .001); diffusing capacity for carbon monoxide corrected for alveolar volume of 155% 4%, 150% 5%, and 120% 3% predicted, respectively( P , .001), with diffusing capacity for nitric oxide and carbon monoxide ratios of 4.7 0.1 at sea level decreased to 3.6 0.1, 3.7 0.1, and 3.9 0.1, respectively ( P , .05) and a maximal exercise mean pulmonary arterial pressure at 56 4, 42 3, and 31 2 mm Hg, respectively ( P , .001). CONCLUSIONS: The aerobic exercise capacity of patients with CMS is preserved in spite of severe pulmonary hypertension and relative hypoventilation, probably by a combination of increased oxygen carrying capacity of the blood and lung diffusion, the latter being predominantly due to an increased capillary blood volume. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Chest
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Altitude en_US
dc.subject Chronic Disease en_US
dc.subject Prognosis en_US
dc.subject Travel en_US
dc.subject Exercise Test en_US
dc.subject Altitude Sickness diagnosis physiopathology en_US
dc.subject Arterial Pressure physiology en_US
dc.subject Echocardiography, Stress en_US
dc.subject Exercise Tolerance physiology en_US
dc.subject Pulmonary Diffusing Capacity physiology en_US
dc.title Exercise pathophysiology in patients with chronic mountain sickness exercise in chronic mountain sickness. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1378/chest.11-2845
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1931-3543


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics