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The accuracy of diagnostic tests for GH deficiency in adults: A systematic review and meta-analysis

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dc.contributor.author Hazem, A.
dc.contributor.author Elamin, M.B.
dc.contributor.author Málaga Rodríguez, Germán Javier
dc.contributor.author Bancos, I.
dc.contributor.author Prevost Ruiz, Yolanda
dc.contributor.author Zeballos-Palacios, C.
dc.contributor.author Velasquez, E.R.
dc.contributor.author Erwin, P.J.
dc.contributor.author Natt, N.
dc.contributor.author Montori, V.M.
dc.contributor.author Murad, M.H.
dc.date.accessioned 2022-01-18T19:34:40Z
dc.date.available 2022-01-18T19:34:40Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11121
dc.description.abstract Context: The diagnostic accuracy of tests used to diagnose GH deficiency (GHD) in adults is unclear. Objective: We conducted a systematic review and meta-analysis of studies that provided data on the available diagnostic tests. Data sources: We searched electronic databases (MEDLINE, EMBASE, Cochrane CENTRAL, Web of Sciences, and Scopus) through April . Study selection: Review of reference lists and contact with experts identified additional candidate studies. Reviewers, working independently and in duplicate, determined study eligibility. Data extraction: Reviewers, working independently and in duplicate, determined the methodological quality of studies and collected descriptive, quality, and outcome data. Data synthesis: Twenty-three studies provided diagnostic accuracy data; none provided patient outcome data. Studies had fair methodological quality, used several reference standards, and included over 1100 patients. Several tests based on direct or indirect stimulation of GH release were associated with good diagnostic accuracy, although most were assessed in one or two studies decreasing the strength of inference due to small sample size. Serum levels of GH or IGF1 had low diagnostic accuracy. Pooled sensitivity and specificity of the two most commonly used stimulation tests were found to be 95 and 89% for the insulin tolerance test and 73 and 81% for the GHRHCarginine test respectively. Meta-analytic estimates for accuracy were associated with substantial heterogeneity. Conclusion: Several tests with reasonable diagnostic accuracy are available for the diagnosis of GHD in adults. The supporting evidence, however, is at high risk of bias (due to heterogeneity, methodological limitations, and imprecision). en_US
dc.language.iso eng
dc.publisher BioScientifica
dc.relation.ispartofseries European Journal of Endocrinology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Cross-Sectional Studies en_US
dc.subject methodology en_US
dc.subject sample size en_US
dc.subject Growth Disorders en_US
dc.subject Longitudinal Studies en_US
dc.subject quality control en_US
dc.subject sensitivity and specificity en_US
dc.subject outcome assessment en_US
dc.subject systematic review en_US
dc.subject diagnostic accuracy en_US
dc.subject Diagnostic Tests, Routine en_US
dc.subject receiver operating characteristic en_US
dc.subject Evidence-Based Medicine en_US
dc.subject Medline en_US
dc.subject reference value en_US
dc.subject Cochrane Library en_US
dc.subject insulin en_US
dc.subject growth hormone deficiency en_US
dc.subject arginine en_US
dc.subject Embase en_US
dc.subject gonadorelin en_US
dc.subject growth hormone release en_US
dc.subject Human Growth Hormone en_US
dc.subject insulin tolerance test en_US
dc.subject medical expert en_US
dc.subject somatomedin C en_US
dc.subject systematic error en_US
dc.title The accuracy of diagnostic tests for GH deficiency in adults: A systematic review and meta-analysis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1530/EJE-11-0476
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1479-683X


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