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Body composition and quality of life in adults treated with GH therapy: A systematic review and meta-analysis

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dc.contributor.author Hazem, A.
dc.contributor.author Elamin, M.B.
dc.contributor.author Bancos, I.
dc.contributor.author Málaga Rodríguez, Germán Javier
dc.contributor.author Prutsky, G.
dc.contributor.author Domecq, J.P.
dc.contributor.author Elraiyah, T.A.
dc.contributor.author Abu Elnour, N.O.
dc.contributor.author Prevost Ruiz, Yolanda
dc.contributor.author PAlmandoz, J.
dc.contributor.author Zeballos-Palacios, C.
dc.contributor.author Velasquez, E.R.
dc.contributor.author Erwin, P.J.
dc.contributor.author Natt, N.
dc.contributor.author Montori, V.M.
dc.contributor.author Murad, M.H.
dc.date.accessioned 2022-01-18T19:34:40Z
dc.date.available 2022-01-18T19:34:40Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11122
dc.description.abstract Objective: To summarise the evidence about the efficacy and safety of using GH in adults with GH deficiency focusing on quality of life and body composition. Data sources: We searched MEDLINE, EMBASE, Cochrane CENTRAL, Web of Science and Scopus throughApril .We also reviewed reference lists and contacted experts to identify candidate studies. Study selection:Reviewers, working independently and in duplicate, selected randomised controlled trials (RCTs) that compared GH to placebo. Data synthesis: We pooled the relative risk (RR) and weighted mean difference (WMD) by the random effects model and assessed heterogeneity using the I 2 statistic. Results: Fifty-four RCTswere included enrolling over 3400 patients. The quality of the included trialswas fair. GH use was associated with statistically significant reduction in weight (WMD, 95% confidence interval (95% CI): K2.31 kg, K2.66 and K1.96) and body fat content (WMD, 95% CI: K2.56 kg, K2.97 andK2.16); increase in lean body mass(WMD,95%CI: 1.38, 1.10 and 1.65), the risk of oedema (RR, 95% CI: 6.07, 4.34 and 8.48) and joint stiffness (RR, 95% CI: 4.17, 1.4 and 12.38); without significant changes in body mass index, bone mineral density or other adverse effects. Quality of life measures improved in 11 of the 16 trials although meta-analysis was not feasible. Results: GH therapy in adults with confirmed GH deficiency reduces weight and body fat, increases lean body mass and increases oedema and joint stiffness. Most trials demonstrated improvement in quality of life measures. en_US
dc.language.iso eng
dc.publisher BioScientifica
dc.relation.ispartofseries European Journal of Endocrinology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject risk factor en_US
dc.subject body fat en_US
dc.subject cardiovascular disease en_US
dc.subject drug efficacy en_US
dc.subject hyperglycemia en_US
dc.subject hypertension en_US
dc.subject placebo en_US
dc.subject body mass en_US
dc.subject body composition en_US
dc.subject outcome assessment en_US
dc.subject systematic review en_US
dc.subject drug safety en_US
dc.subject Quality of Life en_US
dc.subject Clinical Trials as Topic en_US
dc.subject risk reduction en_US
dc.subject dyslipidemia en_US
dc.subject genetic heterogeneity en_US
dc.subject edema en_US
dc.subject Body Composition en_US
dc.subject bone density en_US
dc.subject carpal tunnel syndrome en_US
dc.subject fat content en_US
dc.subject Growth Hormone en_US
dc.subject growth hormone deficiency en_US
dc.subject hormonal therapy en_US
dc.subject joint stiffness en_US
dc.subject lean body weight en_US
dc.subject Pituitary Diseases en_US
dc.subject recurrent cancer en_US
dc.title Body composition and quality of life in adults treated with GH therapy: A systematic review and meta-analysis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1530/EJE-11-0558
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1479-683X


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