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Corticosteroid use in neurocysticercosis

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dc.contributor.author Nash, T.E.
dc.contributor.author Mahanty, S.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2022-01-18T19:34:40Z
dc.date.available 2022-01-18T19:34:40Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11123
dc.description.abstract The cystic larvae of Taenia solium commonly infect the human nervous system, resulting in neurocysticercosis, a major contributor to seizure disorders in most of the world. Inflammation around the parasites is a hallmark of neurocysticercosis pathophysiology. Although mechanisms regulating this inflammation are poorly understood, anti-inflammatory drugs, particularly corticosteroids, have been long used alone or with anthelmintics to manage disease and limit neurological complications and perhaps damage to neural tissues. Only scarce controlled data exist to determine when and what type of corticosteroids and the treatment regime to use. This article revisits the mechanisms of action, rationale, evidence of benefit, safety and problems of corticosteroids in the context of neurocysticercosis, as well as alternative anti-inflammatory strategies to limit the damage caused by inflammation in the CNS. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Expert Review of Neurotherapeutics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Animals en_US
dc.subject review en_US
dc.subject azathioprine en_US
dc.subject drug blood level en_US
dc.subject drug dose reduction en_US
dc.subject drug megadose en_US
dc.subject inflammation en_US
dc.subject low drug dose en_US
dc.subject methotrexate en_US
dc.subject side effect en_US
dc.subject gamma interferon en_US
dc.subject weight gain en_US
dc.subject interleukin 1beta en_US
dc.subject albendazole en_US
dc.subject treatment duration en_US
dc.subject interleukin 2 en_US
dc.subject interleukin 4 en_US
dc.subject interleukin 5 en_US
dc.subject interleukin 6 en_US
dc.subject interleukin 8 en_US
dc.subject tumor necrosis factor alpha en_US
dc.subject Taenia solium en_US
dc.subject taeniasis en_US
dc.subject diabetes mellitus en_US
dc.subject Anthelmintics en_US
dc.subject cysticercosis en_US
dc.subject praziquantel en_US
dc.subject drug safety en_US
dc.subject pathogenesis en_US
dc.subject Neurocysticercosis en_US
dc.subject albendazole sulfoxide en_US
dc.subject methylprednisolone en_US
dc.subject drug mechanism en_US
dc.subject immune response en_US
dc.subject dexamethasone en_US
dc.subject drug withdrawal en_US
dc.subject treatment withdrawal en_US
dc.subject life cycle en_US
dc.subject interleukin 12 en_US
dc.subject anticonvulsive agent en_US
dc.subject seizure en_US
dc.subject corticosteroid therapy en_US
dc.subject brain calcification en_US
dc.subject Adrenal Cortex Hormones en_US
dc.subject Anti-Inflammatory Agents en_US
dc.subject aseptic necrosis en_US
dc.subject brain edema en_US
dc.subject Central Nervous System en_US
dc.subject corticosteroids en_US
dc.subject cycloheximide en_US
dc.subject cyclooxygenase 2 en_US
dc.subject endothelial leukocyte adhesion molecule 1 en_US
dc.subject folic acid en_US
dc.subject hip disease en_US
dc.subject hydrocephalus en_US
dc.subject inducible nitric oxide synthase en_US
dc.subject interleukin 18 en_US
dc.subject monocyte chemotactic protein 1 en_US
dc.subject prednisolone en_US
dc.subject seizures en_US
dc.subject vascular cell adhesion molecule 1 en_US
dc.title Corticosteroid use in neurocysticercosis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1586/ern.11.86
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1744-8360


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