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dc.contributor.author | Huarcaya, E. | |
dc.contributor.author | Best, I. | |
dc.contributor.author | Rodriguez-Tafur, J. | |
dc.contributor.author | Maguiña Vargas, Ciro | |
dc.contributor.author | Solórzano, N. | |
dc.contributor.author | Menacho, J. | |
dc.contributor.author | Lopez de Guimaraes, D. | |
dc.contributor.author | Chauca, J. | |
dc.contributor.author | Ventosilla, P. | |
dc.date.accessioned | 2022-01-18T19:34:40Z | |
dc.date.available | 2022-01-18T19:34:40Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/11126 | |
dc.description.abstract | Human Bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. This cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with Human Bartonellosis. Patients between five and 60 years of age, from endemic areas in Peru, in the acute or chronic phases were included. In patients in the acute phase of Bartonellosis a state of immune peripheral tolerance should be established for persistence of the infection. Our findings were that elevation of the anti-inflammatory cytokine IL-10 and numeric abnormalities of CD4+ and CD8+ T-Lymphocyte counts correlated significantly with an unfavorable immune state. During the chronic phase, the elevated levels of IFN-γ and IL-4 observed in our series correlated with previous findings of endothelial invasion of B. henselae in animal models. | en_US |
dc.description.abstract | La Bartonelosis Humana, tiene una fase aguda caracterizada por fiebre y anemia hemolítica, así como una fase crónica con lesiones semejantes a angiomatosis bacilar. En un estudio transversal piloto los patrones inmunológicos en pacientes con Bartonelosis Humana fueron estudiados mediante muestras pre y post tratamiento. Pacientes entre 5 y 60 años en fase aguda y crónica fueron incluidos en área endémica del Perú. En aquellos pacientes con fase aguda, una fase de tolerancia inmunológica periférica es necesaria para la persistencia de la infección. Los hallazgos de significativa elevación de citoquina anti-inflamatoria (IL-10) y anormalidades numéricas en el recuentos de Linfocitos T CD4+ y CD8+ correlacionan con un estado inmune que favorece la infección. Durante la fase crónica, elevados niveles de INF-γ y IL-4 observados en la serie de pacientes correlacionan con previos hallazgos en modelos animales que favorecen la invasión del endotelio por B. henselae. | es_PE |
dc.language.iso | eng | |
dc.publisher | Instituto de Medicina Tropical de São Paulo | |
dc.relation.ispartofseries | Revista do Instituto de Medicina Tropical de Sao Paulo | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Case-Control Studies | en_US |
dc.subject | Humans | en_US |
dc.subject | Peru | en_US |
dc.subject | preschool child | en_US |
dc.subject | Young Adult | en_US |
dc.subject | Cross-Sectional Studies | en_US |
dc.subject | endemic disease | en_US |
dc.subject | disease severity | en_US |
dc.subject | mortality | en_US |
dc.subject | Pilot Projects | en_US |
dc.subject | pilot study | en_US |
dc.subject | blood | en_US |
dc.subject | clinical article | en_US |
dc.subject | cytokine | en_US |
dc.subject | gamma interferon | en_US |
dc.subject | Th1 cell | en_US |
dc.subject | Th2 cell | en_US |
dc.subject | protein blood level | en_US |
dc.subject | Chronic Disease | en_US |
dc.subject | parasitemia | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Epstein Barr virus infection | en_US |
dc.subject | immunology | en_US |
dc.subject | T-Lymphocytes | en_US |
dc.subject | Acute Disease | en_US |
dc.subject | Bartonella bacilliformis | en_US |
dc.subject | Bartonella Infections | en_US |
dc.subject | bartonellosis | en_US |
dc.subject | Carrion disease | en_US |
dc.subject | chronic disease | en_US |
dc.subject | interleukin 10 | en_US |
dc.subject | interleukin 4 | en_US |
dc.subject | tumor necrosis factor alpha | en_US |
dc.subject | mixed infection | en_US |
dc.subject | leukocyte count | en_US |
dc.subject | CD4+ T lymphocyte | en_US |
dc.subject | transforming growth factor beta | en_US |
dc.subject | cytomegalovirus infection | en_US |
dc.subject | lymphocyte count | en_US |
dc.subject | Human bartonellosis | en_US |
dc.subject | Immunology | en_US |
dc.subject | Carrion's disease | en_US |
dc.subject | CD4-CD8 Ratio | en_US |
dc.subject | CD8+ T lymphocyte | en_US |
dc.subject | immunological tolerance | en_US |
dc.subject | neurobartonellosis | en_US |
dc.subject | pericarditis | en_US |
dc.title | Cytokines and t-lymphocyte count in patients in the acute and chronic phases of bartonella bacilliformis infection in an endemic area in Peru: A pilot study | en_US |
dc.title.alternative | Citoquinas y recuento de Linfocitos T en pacientes en fase aguda y crónica de infección por Bartonella bacilliformis, en una área endémica del Perú: estudio piloto | es_PE |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1590/S0036-46652011000300006 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.06 | |
dc.relation.issn | 1678-9946 |
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