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Aspergilosis pulmonar secundaria a neutropenia inducida por metimazol: reporte de un caso

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dc.contributor.author Pinto, M.E.
dc.contributor.author Banda Flores, Claudia Lizette
dc.contributor.author Seas Ramos, Carlos Rafael
dc.date.accessioned 2022-01-18T19:34:43Z
dc.date.available 2022-01-18T19:34:43Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/11177
dc.description.abstract A 48-year old woman with a recent diagnosis of Graves' disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure. en_US
dc.description.abstract Se reporta el caso de una paciente de 48 años de edad con diagnóstico reciente de enfermedad de Graves, quien acudió a emergencia por presentar fiebre, palpitaciones y dolor faríngeo. Su tratamiento regular incluía metimazol. Al ingreso, los análisis mostraron TSH suprimido, T4 libre elevado y neutropenia. La paciente fue hospitalizada, se administraron antibióticos y factor estimulante de colonia. Después de diez días de tratamiento, la paciente presentó leucocitosis, fiebre y hemoptisis. La tomografía de tórax mostró una cavidad con múltiples nódulos en el lóbulo superior derecho. Los cultivos fueron positivos a Aspergillus fumigatus y Aspergillus flavus. Se inició tratamiento con anfotericina B y luego se cambió a voriconazol, a pesar de lo cual no hubo mejoría del cuadro. La paciente falleció por falla multiorgánica. es_PE
dc.language.iso spa
dc.language.iso eng
dc.publisher Instituto Nacional de Salud
dc.relation.ispartofseries Revista Peruana de Medicina Experimental y Salud Pública
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Case report en_US
dc.subject fever en_US
dc.subject mortality en_US
dc.subject neutropenia en_US
dc.subject computer assisted tomography en_US
dc.subject granulocyte macrophage colony stimulating factor en_US
dc.subject laboratory test en_US
dc.subject hemoptysis en_US
dc.subject multiple organ failure en_US
dc.subject heart palpitation en_US
dc.subject voriconazole en_US
dc.subject drug treatment failure en_US
dc.subject amphotericin B en_US
dc.subject hospital admission en_US
dc.subject emergency ward en_US
dc.subject antibiotic agent en_US
dc.subject drug substitution en_US
dc.subject drug withdrawal en_US
dc.subject fungus culture en_US
dc.subject thyrotropin en_US
dc.subject Graves disease en_US
dc.subject Aspergillus en_US
dc.subject thyroxine en_US
dc.subject sore throat en_US
dc.subject Neutropenia en_US
dc.subject Antithyroid agents en_US
dc.subject Aspergillus flavus en_US
dc.subject Aspergillus fumigatus en_US
dc.subject leukocytosis en_US
dc.subject lung aspergillosis en_US
dc.subject lung nodule en_US
dc.subject Methimazole en_US
dc.subject Pulmonary aspergillosis en_US
dc.subject thiamazole en_US
dc.title Aspergilosis pulmonar secundaria a neutropenia inducida por metimazol: reporte de un caso es_PE
dc.title.alternative Pulmonary aspergillosis Due to methimazole-induced neutropenia: A case report en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1590/S1726-46342012000200015
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1726-4642


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