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dc.contributor.author Hurtado Arestegui, A.
dc.contributor.author Fuquay, R.
dc.contributor.author Sirota, J.
dc.contributor.author Swenson, E.R.
dc.contributor.author Schoene, R.B.
dc.contributor.author Jefferson, J.A.
dc.contributor.author Chen, W.
dc.contributor.author Yu, X.-Q.
dc.contributor.author Kelly, J.P.
dc.contributor.author Johnson, R.J.
dc.contributor.author Escudero, E.
dc.date.accessioned 2022-01-18T19:34:43Z
dc.date.available 2022-01-18T19:34:43Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11192
dc.description.abstract More than 140 million people live permanently at high altitude (>2400 m) under hypoxic conditions that challenge basic physiology. Here we present a short historical review of the populating of these regions and of evidence for genetic adaptations and environmental factors (such as exposure to cobalt) that may influence the phenotypic responses. We also review some of the common renal physiologic responses focusing on clinical manifestations. The frequent presentation of systemic hypertension and microalbuminuria with relatively preserved GFR coupled with the presence of polycythemia and hyperuricemia suggests a new clinical syndrome we term high altitude renal syndrome (HARS). ACE inhibitors appear effective at reducing proteinuria and lowering hemoglobin levels in these patients. en_US
dc.language.iso eng
dc.publisher American Society of Nephrolog
dc.relation.ispartofseries Journal of the American Society of Nephrology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject hemoglobin en_US
dc.subject phenotype en_US
dc.subject priority journal en_US
dc.subject Prevalence en_US
dc.subject glomerulus filtration rate en_US
dc.subject hypertension en_US
dc.subject prevalence en_US
dc.subject Adaptation, Physiological en_US
dc.subject altitude disease en_US
dc.subject Altitude Sickness en_US
dc.subject hypoxia en_US
dc.subject genetic polymorphism en_US
dc.subject drinking water en_US
dc.subject water contamination en_US
dc.subject clinical feature en_US
dc.subject hematocrit en_US
dc.subject cobalt en_US
dc.subject population en_US
dc.subject low birth weight en_US
dc.subject erythropoietin en_US
dc.subject hypoxia inducible factor 2alpha en_US
dc.subject polycythemia en_US
dc.subject hypoxia inducible factor 1alpha en_US
dc.subject environmental factor en_US
dc.subject kidney function en_US
dc.subject dipeptidyl carboxypeptidase inhibitor en_US
dc.subject Attitude en_US
dc.subject Kidney Diseases en_US
dc.subject acetazolamide en_US
dc.subject blood viscosity en_US
dc.subject evolutionary adaptation en_US
dc.subject high altitude renal syndrome en_US
dc.subject hyperuricemia en_US
dc.subject kidney blood flow en_US
dc.subject kidney hypertrophy en_US
dc.subject microalbuminuria en_US
dc.subject proteinuria en_US
dc.subject race difference en_US
dc.subject renin angiotensin aldosterone system en_US
dc.title High altitude renal syndrome (HARS) en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1681/ASN.2010121316
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.20
dc.relation.issn 1533-3450


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