Universidad Peruana Cayetano Heredia

Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate.

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dc.contributor.author Leiva, Karina Paola
dc.contributor.author Rubio, Julio
dc.contributor.author Peralta, Frank
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-01-18T19:34:44Z
dc.date.available 2022-01-18T19:34:44Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11196
dc.description.abstract The present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (EEP) (Punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (LA) administration on sperm production in rats. The effects of EEP were compared with those of ascorbic acid (AA) that is a strong antioxidant and has been shown to reverse lead-induced damage on the reproductive system. The rats were divided into five different groups: those received distilled water (control group), LA, LA with EEP, LA with AA, and EEP alone, respectively. LA administration inhibited spermatogenesis by reducing the length of the stages related to spermiation (VII and VIII) and onset of mitosis (IX-XI). LA-treated rats also showed a reduction in epididymal sperm number and daily sperm production (DSP). Administration of EEP or AA resulted in longer VIII and IX-XI stages when compared with LA-treated rats. Moreover, EEP and AA administration reduced the deleterious effect of LA on DSP and epididymal sperm number. EEP showed an antioxidant activity similar to that of AA. EEP prevented LA-induced spermatogenic disruption in rats and its antioxidant activity could explain its capacity to reverse the damage produced by LA on spermatogenesis. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Toxicology Mechanisms and Methods
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Male en_US
dc.subject controlled study en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject Animals en_US
dc.subject epididymis en_US
dc.subject Plant Extracts en_US
dc.subject Rats en_US
dc.subject Rats, Sprague-Dawley en_US
dc.subject Spermatozoa en_US
dc.subject spermatozoon count en_US
dc.subject seminal vesicle en_US
dc.subject Spermatogenesis en_US
dc.subject Antioxidants en_US
dc.subject weight reduction en_US
dc.subject Organometallic Compounds en_US
dc.subject Phytotherapy en_US
dc.subject antioxidant activity en_US
dc.subject Rattus en_US
dc.subject mitosis en_US
dc.subject Ascorbic Acid en_US
dc.subject Random Allocation en_US
dc.subject lead poisoning en_US
dc.subject meiosis en_US
dc.subject Cell Count en_US
dc.subject daily sperm production en_US
dc.subject Epididymis en_US
dc.subject Fruit en_US
dc.subject Lead acetate en_US
dc.subject Lead Poisoning en_US
dc.subject Lythraceae en_US
dc.subject Mitosis en_US
dc.subject pericarp en_US
dc.subject pomegranate en_US
dc.subject pomegranate ethanolic extract en_US
dc.subject prostate ventral lobe en_US
dc.subject Punica granatum extract en_US
dc.subject Punicaceae en_US
dc.subject reproductive toxicity en_US
dc.subject Seminiferous Tubules en_US
dc.subject sperm number en_US
dc.subject testis en_US
dc.title Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3109/15376516.2011.555789
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.07
dc.relation.issn 1537-6524


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