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Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol.

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dc.contributor.author Rubio, Julio
dc.contributor.author Yucra, Sandra
dc.contributor.author Gasco Tantachuco, Manuel Enrique
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-01-18T19:34:44Z
dc.date.available 2022-01-18T19:34:44Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11197
dc.description.abstract Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose-response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose-response manner due, in part, to its content of polyphenolic compounds. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Toxicology Mechanisms and Methods
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Male en_US
dc.subject Animals en_US
dc.subject Mice en_US
dc.subject Time Factors en_US
dc.subject Dose-Response Relationship, Drug en_US
dc.subject Lepidium chemistry en_US
dc.subject Escape Reaction drug effects en_US
dc.subject Ethanol toxicity en_US
dc.subject Memory Disorders chemically induced drug therapy en_US
dc.subject Plant Extracts chemistry pharmacology en_US
dc.title Dose-response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3109/15376516.2011.583294
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.07
dc.relation.issn 1537-6524


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