dc.contributor.author |
Long, K.Z. |
|
dc.contributor.author |
García Apac, Coralith Marlinda |
|
dc.contributor.author |
Ko, G. |
|
dc.contributor.author |
Santos, J.I. |
|
dc.contributor.author |
Mamun, A.A. |
|
dc.contributor.author |
Rosado, J.L. |
|
dc.contributor.author |
DuPont, H.L. |
|
dc.contributor.author |
Nathakumar, N. |
|
dc.date.accessioned |
2022-01-18T19:34:44Z |
|
dc.date.available |
2022-01-18T19:34:44Z |
|
dc.date.issued |
2011 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/11205 |
|
dc.description.abstract |
Vitamin A supplementation is associated with divergent clinical norovirus (NoV) outcomes in Mexican children. Fecal cytokine concentrations following NoV genogroup infections among 127 Mexican children 5-15 mo old enrolled in a randomized, double-blind, placebo-controlled, vitamin A supplementation trial were determined to clarify the role the gut immune response plays in these associations. Stools collected from supplemented children [20,000 IU retinol (3.3 IU = 1 μg retinol) for children < 12 mo of age; 45,000 IU for children ≥ 12 mo] or children in the placebo group were screened for NoV genogroups I (GI) and II (GII). Monocyte chemoattractant protein-1 (MCP-1), TNFα, IL-5, IL-6, IL-8, IL-4, IFNγ, and IL-10 fecal concentrations were also determined. Differences in cytokine levels between the 2 groups following GI and GII infections were determined using ordered logistic regression models. MCP-1 and IL-8 levels were greater among GI- and GII-infected children, respectively, compared with uninfected children, whereas IL-5 levels were greater following both genogroup infections. MCP-1, IL-8, and IL-6 fecal levels were reduced among supplemented children with GII-associated diarrhea compared with the placebo group. Vitamin A-supplemented, GII-infected children had reduced MCP-1 and TNFα levels compared with GII-infected children in the placebo group (P-interaction = 0.02 and 0.03, respectively). Supplemented children with GI-associated diarrhea had higher TNFα and IL-4 levels compared with children in the placebo group with diarrhea (P-interaction = 0.02 and 0.02, respectively). The divergent effects of supplementation on NoV outcomes may result from the different effects vitamin A has on the genogroup-specific immune responses. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Oxford University Press |
|
dc.relation.ispartofseries |
Journal of Nutrition |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Child |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
preschool child |
en_US |
dc.subject |
controlled study |
en_US |
dc.subject |
major clinical study |
en_US |
dc.subject |
genotype |
en_US |
dc.subject |
Infant |
en_US |
dc.subject |
diarrhea |
en_US |
dc.subject |
drug efficacy |
en_US |
dc.subject |
placebo |
en_US |
dc.subject |
gamma interferon |
en_US |
dc.subject |
protein blood level |
en_US |
dc.subject |
Cytokines |
en_US |
dc.subject |
Feces |
en_US |
dc.subject |
randomized controlled trial |
en_US |
dc.subject |
treatment outcome |
en_US |
dc.subject |
cytokine production |
en_US |
dc.subject |
interleukin 10 |
en_US |
dc.subject |
interleukin 4 |
en_US |
dc.subject |
interleukin 5 |
en_US |
dc.subject |
interleukin 6 |
en_US |
dc.subject |
interleukin 8 |
en_US |
dc.subject |
tumor necrosis factor alpha |
en_US |
dc.subject |
double blind procedure |
en_US |
dc.subject |
Double-Blind Method |
en_US |
dc.subject |
feces culture |
en_US |
dc.subject |
virus strain |
en_US |
dc.subject |
Mexico |
en_US |
dc.subject |
Immunomodulation |
en_US |
dc.subject |
immune response |
en_US |
dc.subject |
screening test |
en_US |
dc.subject |
Caliciviridae Infections |
en_US |
dc.subject |
Norovirus |
en_US |
dc.subject |
innate immunity |
en_US |
dc.subject |
adaptive immunity |
en_US |
dc.subject |
Gastroenteritis |
en_US |
dc.subject |
monocyte chemotactic protein 1 |
en_US |
dc.subject |
Host-Pathogen Interactions |
en_US |
dc.subject |
virus infection |
en_US |
dc.subject |
Chemokines |
en_US |
dc.subject |
Intestines |
en_US |
dc.subject |
Adaptive Immunity |
en_US |
dc.subject |
Dietary Supplements |
en_US |
dc.subject |
Immunity, Innate |
en_US |
dc.subject |
intestine |
en_US |
dc.subject |
Norovirus infection |
en_US |
dc.subject |
retinol |
en_US |
dc.subject |
Vitamin A Deficiency |
en_US |
dc.subject |
vitamin supplementation |
en_US |
dc.title |
Vitamin A modifies the intestinal chemokine and cytokine responses to norovirus infection in mexican children |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.3945/jn.110.132134 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.03.04 |
|
dc.relation.issn |
1541-6100 |
|