Universidad Peruana Cayetano Heredia

Vitamin A modifies the intestinal chemokine and cytokine responses to norovirus infection in mexican children

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dc.contributor.author Long, K.Z.
dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Ko, G.
dc.contributor.author Santos, J.I.
dc.contributor.author Mamun, A.A.
dc.contributor.author Rosado, J.L.
dc.contributor.author DuPont, H.L.
dc.contributor.author Nathakumar, N.
dc.date.accessioned 2022-01-18T19:34:44Z
dc.date.available 2022-01-18T19:34:44Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11205
dc.description.abstract Vitamin A supplementation is associated with divergent clinical norovirus (NoV) outcomes in Mexican children. Fecal cytokine concentrations following NoV genogroup infections among 127 Mexican children 5-15 mo old enrolled in a randomized, double-blind, placebo-controlled, vitamin A supplementation trial were determined to clarify the role the gut immune response plays in these associations. Stools collected from supplemented children [20,000 IU retinol (3.3 IU = 1 μg retinol) for children < 12 mo of age; 45,000 IU for children ≥ 12 mo] or children in the placebo group were screened for NoV genogroups I (GI) and II (GII). Monocyte chemoattractant protein-1 (MCP-1), TNFα, IL-5, IL-6, IL-8, IL-4, IFNγ, and IL-10 fecal concentrations were also determined. Differences in cytokine levels between the 2 groups following GI and GII infections were determined using ordered logistic regression models. MCP-1 and IL-8 levels were greater among GI- and GII-infected children, respectively, compared with uninfected children, whereas IL-5 levels were greater following both genogroup infections. MCP-1, IL-8, and IL-6 fecal levels were reduced among supplemented children with GII-associated diarrhea compared with the placebo group. Vitamin A-supplemented, GII-infected children had reduced MCP-1 and TNFα levels compared with GII-infected children in the placebo group (P-interaction = 0.02 and 0.03, respectively). Supplemented children with GI-associated diarrhea had higher TNFα and IL-4 levels compared with children in the placebo group with diarrhea (P-interaction = 0.02 and 0.02, respectively). The divergent effects of supplementation on NoV outcomes may result from the different effects vitamin A has on the genogroup-specific immune responses. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Nutrition
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Child en_US
dc.subject Humans en_US
dc.subject preschool child en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject genotype en_US
dc.subject Infant en_US
dc.subject diarrhea en_US
dc.subject drug efficacy en_US
dc.subject placebo en_US
dc.subject gamma interferon en_US
dc.subject protein blood level en_US
dc.subject Cytokines en_US
dc.subject Feces en_US
dc.subject randomized controlled trial en_US
dc.subject treatment outcome en_US
dc.subject cytokine production en_US
dc.subject interleukin 10 en_US
dc.subject interleukin 4 en_US
dc.subject interleukin 5 en_US
dc.subject interleukin 6 en_US
dc.subject interleukin 8 en_US
dc.subject tumor necrosis factor alpha en_US
dc.subject double blind procedure en_US
dc.subject Double-Blind Method en_US
dc.subject feces culture en_US
dc.subject virus strain en_US
dc.subject Mexico en_US
dc.subject Immunomodulation en_US
dc.subject immune response en_US
dc.subject screening test en_US
dc.subject Caliciviridae Infections en_US
dc.subject Norovirus en_US
dc.subject innate immunity en_US
dc.subject adaptive immunity en_US
dc.subject Gastroenteritis en_US
dc.subject monocyte chemotactic protein 1 en_US
dc.subject Host-Pathogen Interactions en_US
dc.subject virus infection en_US
dc.subject Chemokines en_US
dc.subject Intestines en_US
dc.subject Adaptive Immunity en_US
dc.subject Dietary Supplements en_US
dc.subject Immunity, Innate en_US
dc.subject intestine en_US
dc.subject Norovirus infection en_US
dc.subject retinol en_US
dc.subject Vitamin A Deficiency en_US
dc.subject vitamin supplementation en_US
dc.title Vitamin A modifies the intestinal chemokine and cytokine responses to norovirus infection in mexican children en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3945/jn.110.132134
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.04
dc.relation.issn 1541-6100


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