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dc.contributor.author | Long, K.Z. | |
dc.contributor.author | García Apac, Coralith Marlinda | |
dc.contributor.author | Ko, G. | |
dc.contributor.author | Santos, J.I. | |
dc.contributor.author | Mamun, A.A. | |
dc.contributor.author | Rosado, J.L. | |
dc.contributor.author | DuPont, H.L. | |
dc.contributor.author | Nathakumar, N. | |
dc.date.accessioned | 2022-01-18T19:34:44Z | |
dc.date.available | 2022-01-18T19:34:44Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/11205 | |
dc.description.abstract | Vitamin A supplementation is associated with divergent clinical norovirus (NoV) outcomes in Mexican children. Fecal cytokine concentrations following NoV genogroup infections among 127 Mexican children 5-15 mo old enrolled in a randomized, double-blind, placebo-controlled, vitamin A supplementation trial were determined to clarify the role the gut immune response plays in these associations. Stools collected from supplemented children [20,000 IU retinol (3.3 IU = 1 μg retinol) for children < 12 mo of age; 45,000 IU for children ≥ 12 mo] or children in the placebo group were screened for NoV genogroups I (GI) and II (GII). Monocyte chemoattractant protein-1 (MCP-1), TNFα, IL-5, IL-6, IL-8, IL-4, IFNγ, and IL-10 fecal concentrations were also determined. Differences in cytokine levels between the 2 groups following GI and GII infections were determined using ordered logistic regression models. MCP-1 and IL-8 levels were greater among GI- and GII-infected children, respectively, compared with uninfected children, whereas IL-5 levels were greater following both genogroup infections. MCP-1, IL-8, and IL-6 fecal levels were reduced among supplemented children with GII-associated diarrhea compared with the placebo group. Vitamin A-supplemented, GII-infected children had reduced MCP-1 and TNFα levels compared with GII-infected children in the placebo group (P-interaction = 0.02 and 0.03, respectively). Supplemented children with GI-associated diarrhea had higher TNFα and IL-4 levels compared with children in the placebo group with diarrhea (P-interaction = 0.02 and 0.02, respectively). The divergent effects of supplementation on NoV outcomes may result from the different effects vitamin A has on the genogroup-specific immune responses. | en_US |
dc.language.iso | eng | |
dc.publisher | Oxford University Press | |
dc.relation.ispartofseries | Journal of Nutrition | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Child | en_US |
dc.subject | Humans | en_US |
dc.subject | preschool child | en_US |
dc.subject | controlled study | en_US |
dc.subject | major clinical study | en_US |
dc.subject | genotype | en_US |
dc.subject | Infant | en_US |
dc.subject | diarrhea | en_US |
dc.subject | drug efficacy | en_US |
dc.subject | placebo | en_US |
dc.subject | gamma interferon | en_US |
dc.subject | protein blood level | en_US |
dc.subject | Cytokines | en_US |
dc.subject | Feces | en_US |
dc.subject | randomized controlled trial | en_US |
dc.subject | treatment outcome | en_US |
dc.subject | cytokine production | en_US |
dc.subject | interleukin 10 | en_US |
dc.subject | interleukin 4 | en_US |
dc.subject | interleukin 5 | en_US |
dc.subject | interleukin 6 | en_US |
dc.subject | interleukin 8 | en_US |
dc.subject | tumor necrosis factor alpha | en_US |
dc.subject | double blind procedure | en_US |
dc.subject | Double-Blind Method | en_US |
dc.subject | feces culture | en_US |
dc.subject | virus strain | en_US |
dc.subject | Mexico | en_US |
dc.subject | Immunomodulation | en_US |
dc.subject | immune response | en_US |
dc.subject | screening test | en_US |
dc.subject | Caliciviridae Infections | en_US |
dc.subject | Norovirus | en_US |
dc.subject | innate immunity | en_US |
dc.subject | adaptive immunity | en_US |
dc.subject | Gastroenteritis | en_US |
dc.subject | monocyte chemotactic protein 1 | en_US |
dc.subject | Host-Pathogen Interactions | en_US |
dc.subject | virus infection | en_US |
dc.subject | Chemokines | en_US |
dc.subject | Intestines | en_US |
dc.subject | Adaptive Immunity | en_US |
dc.subject | Dietary Supplements | en_US |
dc.subject | Immunity, Innate | en_US |
dc.subject | intestine | en_US |
dc.subject | Norovirus infection | en_US |
dc.subject | retinol | en_US |
dc.subject | Vitamin A Deficiency | en_US |
dc.subject | vitamin supplementation | en_US |
dc.title | Vitamin A modifies the intestinal chemokine and cytokine responses to norovirus infection in mexican children | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.3945/jn.110.132134 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.04 | |
dc.relation.issn | 1541-6100 |
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