Universidad Peruana Cayetano Heredia

Lack of molecular correlates of Plasmodium vivax ookinete development

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dc.contributor.author Bounkeua, V.
dc.contributor.author Li, F.
dc.contributor.author Chuquiyauri, R.
dc.contributor.author Abeles, S.R.
dc.contributor.author McClean, C.M.
dc.contributor.author Neyra, V.
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Yori, P.P.
dc.contributor.author Vinetz, Joseph Michael
dc.date.accessioned 2022-01-18T19:35:51Z
dc.date.available 2022-01-18T19:35:51Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11214
dc.description.abstract Previous studies of Plasmodium vivax transmission to Anopheles spp. mosquitoes have not been able to predict mosquito infectivity on the basis of microscopic or molecular quantification of parasites (total parasites in the sample or total number of gametocytes) in infected blood. Two methods for production of P. vivax ookinete cultures in vitro, with yields of 106 macrogametocytes, 104 zygotes, and 103 ookinetes, respectively, per 10 mL of P. vivax-infected patient blood with approximately 0.01% parasitemia, were used to study P. vivax sexual stage development. The quantity of gametocytes, determined by counting Giemsa-stained blood smears, and quantity and type of gametocyte as determined by quantitative reverse transcriptase-polymerase chain reaction for Pvalpha tubulin II and macrogametocyte-specific pvg377 did not predict ookinete yield. Factors that affect the efficiency of in vitro P. vivax ookinete transformation remain poorly understood. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject in vitro study en_US
dc.subject non Plasmodium vivax en_US
dc.subject sex ratio en_US
dc.subject clinical article en_US
dc.subject parasitemia en_US
dc.subject Reverse Transcriptase Polymerase Chain Reaction en_US
dc.subject Malaria, Vivax en_US
dc.subject Plasmodium vivax malaria en_US
dc.subject Antimalarials en_US
dc.subject blood smear en_US
dc.subject Cells, Cultured en_US
dc.subject gametocyte en_US
dc.subject maturity en_US
dc.subject ookinete development en_US
dc.subject reverse transcription polymerase chain reaction en_US
dc.subject sexual development en_US
dc.subject xanthurenic acid en_US
dc.subject zygote en_US
dc.title Lack of molecular correlates of Plasmodium vivax ookinete development en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.2011.10-0729
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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