Universidad Peruana Cayetano Heredia

Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.

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dc.contributor.author Bravo Puccio, Francisco Gerardo
dc.contributor.author Chian, Cesar
dc.date.accessioned 2022-01-18T19:35:51Z
dc.date.available 2022-01-18T19:35:51Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/11221
dc.description.abstract Context: Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and deceive pathologists dealing with such cases. OBJECTIVES: To make pathologists aware of the histologic findings during early phases of acral lentiginous melanoma (including the in situ phase), to compare those findings with what is seen in acral junctional nevus, and to highlight their similarities and differences. This review will also emphasize the important clinical and dermatoscopic findings to be considered when diagnosing acral lentiginous melanoma. DATA SOURCES: Review of published articles on the epidemiology; the clinical, dermatoscopic, and histopathologic findings; and the molecular biology of acral lentiginous melanoma as well as the personal experience ofs when dealing with such cases. CONCLUSIONS: Acral lentiginous melanoma is a clinicopathologic entity with a clear-cut clinical picture: a diameter larger than 0.7 mm; ill-defined, darkly pigmented, flat lesion with irregular borders on acral locations; and the presence of mostly single-cell proliferations of melanocytes along the dermo-epidermal junction. Along with a few additional criteria, these findings should be sufficient to allow the pathologist to make the diagnosis and to recommend complete excision. Fluent communication between clinician and pathologist will facilitate a correct diagnosis. en_US
dc.language.iso eng
dc.publisher College of American Pathologists
dc.relation.ispartofseries Archives of Pathology & Laboratory Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject pathology en_US
dc.subject Prevalence en_US
dc.subject Skin Neoplasms en_US
dc.subject skin tumor en_US
dc.subject Diagnosis, Differential en_US
dc.subject Nevus, Pigmented en_US
dc.subject Hutchinson's Melanotic Freckle en_US
dc.subject malignant lentigo en_US
dc.subject pigmented nevus en_US
dc.title Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation. en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.5858/2010-0323-RAR.1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 1543-2165


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