Zika Virus Seroprevalence in Two Districts of Chincha, Ica, Peru: A Cross-Sectional Study.

de Lamballerie, Xavier; Schwalb Calderon, Alvaro; Guerra, Humberto; Jaenisch, Thomas; Gotuzzo Herencia, José Eduardo; Merino, Xiomara; Pezzi, Laura; Suarez-Ognio, Luis; Cachay Figueroa, Rodrigo Antonio; Talledo Albujar, Michael John; Acevedo-Rodriguez, J. Gonzalo

dc.contributor.author	Cachay Figueroa, Rodrigo Antonio
dc.contributor.author	Schwalb Calderon, Alvaro
dc.contributor.author	Acevedo-Rodriguez, J. Gonzalo
dc.contributor.author	Merino, Xiomara
dc.contributor.author	Talledo Albujar, Michael John
dc.contributor.author	Suarez-Ognio, Luis
dc.contributor.author	Pezzi, Laura
dc.contributor.author	de Lamballerie, Xavier
dc.contributor.author	Guerra, Humberto
dc.contributor.author	Jaenisch, Thomas
dc.contributor.author	Gotuzzo Herencia, José Eduardo
dc.date.accessioned	2022-02-01T21:18:26Z
dc.date.available	2022-02-01T21:18:26Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/20.500.12866/11267
dc.description.abstract	In 2017, a major outbreak of Zika virus (ZIKV) infection took place in Chincha Province, Peru, where arboviral circulation had never been reported before. We conducted a cross-sectional survey (March-May 2019) in two districts of Chincha Province: Pueblo Nuevo and Chincha Baja. We included residents who were 20 to 40 years old and who had lived in these districts for at least 1 year. Serological testing combined screening with a commercial NS1 protein-based Zika IgG ELISA, and confirmation by a cytopathic effect-based virus neutralization test (VNT). Prevalence ratios (PRs) were calculated using Poisson regression with robust error variance. Four hundred participants, divided equally among districts, were enrolled. Anti-ZIKV IgG ELISA was positive for 42 participants (10.5%) and borderline for 12 (3%). Fifty-two of these 54 samples were confirmed positive by ZIKV VNT (13% of the total population). The Pueblo Nuevo district exhibited a greater ZIKV seroprevalence based on VNT results than the Chincha Baja district (23.5% versus 2.5%), with participants from the Pueblo Nuevo district being 9.4 times more likely to have a positive ZIKV VNT result. Average monthly income greater than the minimum wage and adequate water storage were found to be protective factors (PR, 0.29 and 0.24, respectively). In multivariate analysis, living in the Pueblo Nuevo district and a personal history of fever and rash were strong predictors of ZIKV positivity by VNT. The low ZIKV seroprevalence should prompt health authorities to stimulate interventions to prevent potential future outbreaks. In the Pueblo Nuevo district, the seroprevalence was greater but presumably not sufficient to ensure protective herd immunity	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Zika Virus Seroprevalence	en_US
dc.subject	Chincha	en_US
dc.subject	Ica	en_US
dc.subject	Peru	en_US
dc.subject	Cross-Sectional Study	en_US
dc.title	Zika Virus Seroprevalence in Two Districts of Chincha, Ica, Peru: A Cross-Sectional Study.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.20-1339
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645