dc.contributor.author |
Kamenar, Katarina |
|
dc.contributor.author |
Hossen, Shakir |
|
dc.contributor.author |
Gupte, Akshay N. |
|
dc.contributor.author |
Siddharthan, Trishul |
|
dc.contributor.author |
Pollard, Suzanne |
|
dc.contributor.author |
Chowdhury, Muhammad |
|
dc.contributor.author |
Rubinstein, Adolfo L. |
|
dc.contributor.author |
Irazola, Vilma E. |
|
dc.contributor.author |
Gutierrez, Laura |
|
dc.contributor.author |
Miranda, J. Jaime |
|
dc.contributor.author |
Bernabé Ortiz, Antonio |
|
dc.contributor.author |
Alam, Dewan |
|
dc.contributor.author |
Kirenga, Bruce |
|
dc.contributor.author |
Jones, Rupert C. |
|
dc.contributor.author |
van Gemert, Frederik |
|
dc.contributor.author |
Wise, Robert A. |
|
dc.contributor.author |
Checkley, William |
|
dc.date.accessioned |
2022-02-01T21:18:26Z |
|
dc.date.available |
2022-02-01T21:18:26Z |
|
dc.date.issued |
2021 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/11271 |
|
dc.description.abstract |
BACKGROUND: Risk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as pulmonary tuberculosis. We sought to study the association between previous tuberculosis disease and COPD by using pooled population-based cross-sectional data in 13 geographically diverse, low-resource settings. METHODS: We pooled six cohorts in 13 different LMIC settings, 6 countries and 3 continents to study the relationship between self-reported previous tuberculosis disease and lung function outcomes including COPD (defined as a postbronchodilator forced expiratory volume in one second (FEV(1))/forced vital capacity (FVC) below the lower limit of normal). Multivariable regressions with random effects were used to examine the association between previous tuberculosis disease and lung function outcomes. RESULTS: We analysed data for 12 396 participants (median age 54.0 years, 51.5% male); 332 (2.7%) of the participants had previous tuberculosis disease. Overall prevalence of COPD was 8.8% (range 1.7%-15.5% across sites). COPD was four times more common among those with previous tuberculosis disease (25.7% vs 8.3% without previous tuberculosis disease, p<0.001). The adjusted odds of having COPD was 3.78 times higher (95% CI 2.87 to 4.98) for participants with previous tuberculosis disease than those without a history of tuberculosis disease. The attributable fraction of COPD due to previous tuberculosis disease in the study sample was 6.9% (95% CI 4.8% to 9.6%). Participants with previous tuberculosis disease also had lower prebronchodilator Z-scores for FEV(1) (-0.70, 95% CI -0.84 to -0.55), FVC (-0.44, 95% CI -0.59 to -0.29) and the FEV(1):FVC ratio (-0.63, 95% CI -0.76 to -0.51) when compared with those without previous tuberculosis disease. CONCLUSIONS: Previous tuberculosis disease is a significant and under-recognised risk factor for COPD and poor lung function in LMICs. Better tuberculosis control will also likely reduce the global burden of COPD |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
BMJ Publishing Group |
|
dc.relation.ispartofseries |
Thorax |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
tuberculosis |
en_US |
dc.subject |
COPD epidemiology |
en_US |
dc.title |
Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies. |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1136/thoraxjnl-2020-216500 |
|
dc.relation.issn |
1468-3296 |
|