Universidad Peruana Cayetano Heredia

Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies.

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dc.contributor.author Kamenar, Katarina
dc.contributor.author Hossen, Shakir
dc.contributor.author Gupte, Akshay N.
dc.contributor.author Siddharthan, Trishul
dc.contributor.author Pollard, Suzanne
dc.contributor.author Chowdhury, Muhammad
dc.contributor.author Rubinstein, Adolfo L.
dc.contributor.author Irazola, Vilma E.
dc.contributor.author Gutierrez, Laura
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Bernabé Ortiz, Antonio
dc.contributor.author Alam, Dewan
dc.contributor.author Kirenga, Bruce
dc.contributor.author Jones, Rupert C.
dc.contributor.author van Gemert, Frederik
dc.contributor.author Wise, Robert A.
dc.contributor.author Checkley, William
dc.date.accessioned 2022-02-01T21:18:26Z
dc.date.available 2022-02-01T21:18:26Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11271
dc.description.abstract BACKGROUND: Risk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as pulmonary tuberculosis. We sought to study the association between previous tuberculosis disease and COPD by using pooled population-based cross-sectional data in 13 geographically diverse, low-resource settings. METHODS: We pooled six cohorts in 13 different LMIC settings, 6 countries and 3 continents to study the relationship between self-reported previous tuberculosis disease and lung function outcomes including COPD (defined as a postbronchodilator forced expiratory volume in one second (FEV(1))/forced vital capacity (FVC) below the lower limit of normal). Multivariable regressions with random effects were used to examine the association between previous tuberculosis disease and lung function outcomes. RESULTS: We analysed data for 12 396 participants (median age 54.0 years, 51.5% male); 332 (2.7%) of the participants had previous tuberculosis disease. Overall prevalence of COPD was 8.8% (range 1.7%-15.5% across sites). COPD was four times more common among those with previous tuberculosis disease (25.7% vs 8.3% without previous tuberculosis disease, p<0.001). The adjusted odds of having COPD was 3.78 times higher (95% CI 2.87 to 4.98) for participants with previous tuberculosis disease than those without a history of tuberculosis disease. The attributable fraction of COPD due to previous tuberculosis disease in the study sample was 6.9% (95% CI 4.8% to 9.6%). Participants with previous tuberculosis disease also had lower prebronchodilator Z-scores for FEV(1) (-0.70, 95% CI -0.84 to -0.55), FVC (-0.44, 95% CI -0.59 to -0.29) and the FEV(1):FVC ratio (-0.63, 95% CI -0.76 to -0.51) when compared with those without previous tuberculosis disease. CONCLUSIONS: Previous tuberculosis disease is a significant and under-recognised risk factor for COPD and poor lung function in LMICs. Better tuberculosis control will also likely reduce the global burden of COPD en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Thorax
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject tuberculosis en_US
dc.subject COPD epidemiology en_US
dc.title Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/thoraxjnl-2020-216500
dc.relation.issn 1468-3296


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