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dc.contributor.author | Kamenar, Katarina | |
dc.contributor.author | Hossen, Shakir | |
dc.contributor.author | Gupte, Akshay N. | |
dc.contributor.author | Siddharthan, Trishul | |
dc.contributor.author | Pollard, Suzanne | |
dc.contributor.author | Chowdhury, Muhammad | |
dc.contributor.author | Rubinstein, Adolfo L. | |
dc.contributor.author | Irazola, Vilma E. | |
dc.contributor.author | Gutierrez, Laura | |
dc.contributor.author | Miranda, J. Jaime | |
dc.contributor.author | Bernabé Ortiz, Antonio | |
dc.contributor.author | Alam, Dewan | |
dc.contributor.author | Kirenga, Bruce | |
dc.contributor.author | Jones, Rupert C. | |
dc.contributor.author | van Gemert, Frederik | |
dc.contributor.author | Wise, Robert A. | |
dc.contributor.author | Checkley, William | |
dc.date.accessioned | 2022-02-01T21:18:26Z | |
dc.date.available | 2022-02-01T21:18:26Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/11271 | |
dc.description.abstract | BACKGROUND: Risk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as pulmonary tuberculosis. We sought to study the association between previous tuberculosis disease and COPD by using pooled population-based cross-sectional data in 13 geographically diverse, low-resource settings. METHODS: We pooled six cohorts in 13 different LMIC settings, 6 countries and 3 continents to study the relationship between self-reported previous tuberculosis disease and lung function outcomes including COPD (defined as a postbronchodilator forced expiratory volume in one second (FEV(1))/forced vital capacity (FVC) below the lower limit of normal). Multivariable regressions with random effects were used to examine the association between previous tuberculosis disease and lung function outcomes. RESULTS: We analysed data for 12 396 participants (median age 54.0 years, 51.5% male); 332 (2.7%) of the participants had previous tuberculosis disease. Overall prevalence of COPD was 8.8% (range 1.7%-15.5% across sites). COPD was four times more common among those with previous tuberculosis disease (25.7% vs 8.3% without previous tuberculosis disease, p<0.001). The adjusted odds of having COPD was 3.78 times higher (95% CI 2.87 to 4.98) for participants with previous tuberculosis disease than those without a history of tuberculosis disease. The attributable fraction of COPD due to previous tuberculosis disease in the study sample was 6.9% (95% CI 4.8% to 9.6%). Participants with previous tuberculosis disease also had lower prebronchodilator Z-scores for FEV(1) (-0.70, 95% CI -0.84 to -0.55), FVC (-0.44, 95% CI -0.59 to -0.29) and the FEV(1):FVC ratio (-0.63, 95% CI -0.76 to -0.51) when compared with those without previous tuberculosis disease. CONCLUSIONS: Previous tuberculosis disease is a significant and under-recognised risk factor for COPD and poor lung function in LMICs. Better tuberculosis control will also likely reduce the global burden of COPD | en_US |
dc.language.iso | eng | |
dc.publisher | BMJ Publishing Group | |
dc.relation.ispartofseries | Thorax | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | tuberculosis | en_US |
dc.subject | COPD epidemiology | en_US |
dc.title | Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies. | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1136/thoraxjnl-2020-216500 | |
dc.relation.issn | 1468-3296 |
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