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Association between Iron Supplementation and the Presence of Diarrhea in Peruvian Children Aged 6-59 Months: Analysis of the Database of the Demographic Health Survey in Peru (DHS, Peru), Years 2009-2019.

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dc.contributor.author Valverde-Bruffau, Valeria Janice
dc.contributor.author Steenland, Kyle
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2022-02-01T21:18:26Z
dc.date.available 2022-02-01T21:18:26Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11273
dc.description.abstract INTRODUCTION: According to the World Health Organization (WHO), anemia is a severe public health problem when the prevalence is ≥ 40%. In 2019, in Peru, 40.1% of children (age 6 to 35 months) are diagnosed as anemic. This is a concern since, despite the efforts of the governments to reduce the prevalence, the problem has stagnated since 2011. The treatment applied to deal with anemia is iron supplementation. Although iron is essential for cell function, an excess can produce adverse responses, such as gut inflammation affecting microbiota and resulting in diarrheic episodes. OBJECTIVE: To determine the association between diarrhea and iron supplementation in children with and without anemia, controlling for different socio-demographic variables. DESIGN: We conducted via logistic regression to obtain diarrhea prevalence ratios, adjusted by age, sex, geographic region, water and sanitation service, and rurality. The survey asked for recent episodes of diarrhea during the last 7 days; similarly, after the consumption of iron supplements during the last 12 months before the survey. SETTING: Peru. SUBJECTS: The Demographic and Health Survey (DHS) is conducted annually at home among 14,202 children on average (2009 - 2019). RESULTS: Iron supplementation in the last seven days (PR=1.09) or the last twelve months (PR=1.19) (p<0.0001) was associated with an increased risk of diarrhea. The same association was observed between iron supplementation and the presence of anemia. CONCLUSIONS: Iron supplementation is associated with diarrhea and over-use in children should be avoided en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartofseries Public Health Nutrition
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject diarrhea en_US
dc.subject drinking water en_US
dc.subject anemia en_US
dc.subject sewage en_US
dc.subject iron supplement en_US
dc.title Association between Iron Supplementation and the Presence of Diarrhea in Peruvian Children Aged 6-59 Months: Analysis of the Database of the Demographic Health Survey in Peru (DHS, Peru), Years 2009-2019. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/S1368980021004808
dc.relation.issn 1475-2727


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