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Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru.

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dc.contributor.author Benavides, Julio A.
dc.contributor.author Godreuil, Sylvain
dc.contributor.author Opazo-Capurro, Andrés
dc.contributor.author Mahamat, Oumar O.
dc.contributor.author Falcon Perez, Nestor Gerardo
dc.contributor.author Oravcova, Katarina
dc.contributor.author Streicker, Daniel G.
dc.contributor.author Shiva Ramayoni, Carlos Martin
dc.date.accessioned 2022-02-01T21:18:26Z
dc.date.available 2022-02-01T21:18:26Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11277
dc.description.abstract Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) have been reported in wildlife worldwide. Whether wildlife is a transient host of ESBL-E. coli or comprises an independently maintained reservoir is unknown. We investigated this question by longitudinally monitoring ESBL-E. coli in common vampire bats and nearby livestock in Peru. Among 388 bats from five vampire bat colonies collected over three years, ESBL-E. coli were detected at a low prevalence (10% in 2015, 4% in 2017 and 2018) compared to a high prevalence (48%) from 134 livestock sampled in 2017. All ESBL-E. coli were multidrug-resistant, and whole genome sequencing of 33 randomly selected ESBL-E. coli isolates (18 recovered from bats) detected 46 genes conferring resistance to antibiotics including third-generation cephalosporins (e.g., bla(CTX-M-55), bla(CTX-M-15), bla(CTX-M-65), bla(CTX-M-3), bla(CTX-M-14)), aminoglycosides, fluoroquinolones, and colistin (mcr-1). The mcr-1 gene is reported for the first time on a wild bat in Latin America. ESBL-E. coli also carried 31 plasmid replicon types and 16 virulence genes. Twenty-three E. coli sequence types (STs) were detected, including STs involved in clinical infections worldwide (e.g., ST 167, ST 117, ST 10, ST 156 and ST 648). ESBL-E. coli with identical cgMLST (ST 167) were detected in the same bat roost in 2015 and 2017, and several ESBL-E. coli from different bat roosts clustered together in the cgMLST reconstruction, suggesting long-term maintenance of ESBL-E. coli within bats. Most antibiotic resistance and virulence genes were detected in E. coli from both host populations, while ESBL-E. coli ST 744 was found in a bat and a pig from the same locality, suggesting possible cross-species exchanges of genetic material and/or bacteria between bats and livestock. This study suggests that wild mammals can maintain multidrug-resistant bacteria and share them with livestock en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Science of the Total Environment
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Latin America en_US
dc.subject Antimicrobial resistance en_US
dc.subject E. coli en_US
dc.subject Extended-spectrum beta-lactamase en_US
dc.subject mcr-1 en_US
dc.subject Wildlife en_US
dc.title Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.scitotenv.2021.152045
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.05.08
dc.relation.issn 1879-1026


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