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dc.contributor.author | Benavides, Julio A. | |
dc.contributor.author | Godreuil, Sylvain | |
dc.contributor.author | Opazo-Capurro, Andrés | |
dc.contributor.author | Mahamat, Oumar O. | |
dc.contributor.author | Falcon Perez, Nestor Gerardo | |
dc.contributor.author | Oravcova, Katarina | |
dc.contributor.author | Streicker, Daniel G. | |
dc.contributor.author | Shiva Ramayoni, Carlos Martin | |
dc.date.accessioned | 2022-02-01T21:18:26Z | |
dc.date.available | 2022-02-01T21:18:26Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/11277 | |
dc.description.abstract | Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) have been reported in wildlife worldwide. Whether wildlife is a transient host of ESBL-E. coli or comprises an independently maintained reservoir is unknown. We investigated this question by longitudinally monitoring ESBL-E. coli in common vampire bats and nearby livestock in Peru. Among 388 bats from five vampire bat colonies collected over three years, ESBL-E. coli were detected at a low prevalence (10% in 2015, 4% in 2017 and 2018) compared to a high prevalence (48%) from 134 livestock sampled in 2017. All ESBL-E. coli were multidrug-resistant, and whole genome sequencing of 33 randomly selected ESBL-E. coli isolates (18 recovered from bats) detected 46 genes conferring resistance to antibiotics including third-generation cephalosporins (e.g., bla(CTX-M-55), bla(CTX-M-15), bla(CTX-M-65), bla(CTX-M-3), bla(CTX-M-14)), aminoglycosides, fluoroquinolones, and colistin (mcr-1). The mcr-1 gene is reported for the first time on a wild bat in Latin America. ESBL-E. coli also carried 31 plasmid replicon types and 16 virulence genes. Twenty-three E. coli sequence types (STs) were detected, including STs involved in clinical infections worldwide (e.g., ST 167, ST 117, ST 10, ST 156 and ST 648). ESBL-E. coli with identical cgMLST (ST 167) were detected in the same bat roost in 2015 and 2017, and several ESBL-E. coli from different bat roosts clustered together in the cgMLST reconstruction, suggesting long-term maintenance of ESBL-E. coli within bats. Most antibiotic resistance and virulence genes were detected in E. coli from both host populations, while ESBL-E. coli ST 744 was found in a bat and a pig from the same locality, suggesting possible cross-species exchanges of genetic material and/or bacteria between bats and livestock. This study suggests that wild mammals can maintain multidrug-resistant bacteria and share them with livestock | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Science of the Total Environment | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Latin America | en_US |
dc.subject | Antimicrobial resistance | en_US |
dc.subject | E. coli | en_US |
dc.subject | Extended-spectrum beta-lactamase | en_US |
dc.subject | mcr-1 | en_US |
dc.subject | Wildlife | en_US |
dc.title | Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru. | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.scitotenv.2021.152045 | |
dc.relation.issn | 1879-1026 |
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