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Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru.

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dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Bustamante Rufino, Ana Beatriz
dc.contributor.author García Apac, Coralith Marlinda
dc.contributor.author Neyra Valdez, Lidio Edgar
dc.contributor.author Mendoza, Karina
dc.contributor.author Calderón, Enrique J.
dc.contributor.author Le Gal, Solene
dc.contributor.author Miller, Robert F.
dc.contributor.author Ponce, Carolina A.
dc.contributor.author Nevez, Gilles
dc.contributor.author Vargas, Sergio L.
dc.date.accessioned 2022-02-01T21:18:27Z
dc.date.available 2022-02-01T21:18:27Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11282
dc.description.abstract OBJECTIVES: To provide original data on Pneumocystis primary infection in non-immunosuppressed infants from Peru. METHODS: A cross sectional study was performed. Infants less than seven months old, without any underlying medical conditions attending the "well baby" outpatient clinic at one hospital in Lima, Peru were prospectively enrolled during a 15-month period from November 2016 to February 2018. All had a nasopharyngeal aspirate (NPA) for detection of P. jirovecii DNA using a PCR assay, regardless of respiratory symptoms. P. jirovecii DNA detection was considered to represent pulmonary colonization contemporaneous with Pneumocystis primary infection. Associations between infants' clinical and demographic characteristics and results of P. jirovecii DNA detection were analyzed. RESULTS: P. jirovecii DNA was detected in 45 of 146 infants (30.8%) and detection was not associated with concurrent respiratory symptoms in 40 of 45 infants. Infants with P. jirovecii had a lower mean age when compared to infants not colonized (p <0.05). The highest frequency of P. jirovecii was observed in 2-3-month-old infants (p < 0.01) and in the cooler winter and spring seasons (p <0.01). Multivariable analysis showed that infants living in a home with ≤ 1 bedroom were more likely to be colonized; Odds Ratio =3.03 (95%CI 1.31-7.00; p = 0.01). CONCLUSION: Pneumocystis primary infection in this single site in Lima, Peru, was most frequently observed in 2-3-month-old infants, in winter and spring seasons, and with higher detection rates being associated with household conditions favoring close inter-individual contacts and potential transmission of P. jirovecii en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal de Mycologie Médicale
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Infants en_US
dc.subject Pneumocystis jirovecii,Pulmonary colonization en_US
dc.subject Primary infection en_US
dc.title Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.mycmed.2021.101202
dc.relation.issn 1773-0449


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