Universidad Peruana Cayetano Heredia

Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders.

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dc.contributor.author Patrician, Alexander
dc.contributor.author Dawkins, Tony
dc.contributor.author Coombs, Geoff B.
dc.contributor.author Stacey, Benjamin
dc.contributor.author Gasho, Christopher
dc.contributor.author Gibbons, Travis
dc.contributor.author Howe, Connor A.
dc.contributor.author Tremblay, Joshua C.
dc.contributor.author Stone, Rachel
dc.contributor.author Tymko, Kaitlyn
dc.contributor.author Tymko, Courtney
dc.contributor.author Akins, John D.
dc.contributor.author Hoiland, Ryan L.
dc.contributor.author Vizcardo-Galindo, Gustavo A.
dc.contributor.author Figueroa-Mujíca, Rómulo
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Bailey, Damian M.
dc.contributor.author Stembridge, Michael
dc.contributor.author Anholm, James D.
dc.contributor.author Tymko, Michael M.
dc.contributor.author Ainslie, Philip N.
dc.date.accessioned 2022-02-01T21:18:27Z
dc.date.available 2022-02-01T21:18:27Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11284
dc.description.abstract BACKGROUND: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andeans with chronic mountain sickness (CMS) is resistant to iron administration. Although pulmonary vascular remodeling and hypertension are characteristic features of CMS, the effect of iron administration in healthy Andeans, to our knowledge, has not been investigated. If the interplay between iron status and pulmonary vascular tone in healthy Andeans remains intact, this could provide valuable clinical insight into the role of iron regulation at high altitude. RESEARCH QUESTION: Is the pulmonary vasculature in healthy Andeans responsive to iron infusion? STUDY DESIGN AND METHODS: In a double-blinded, block-randomized design, 24 healthy high-altitude Andeans and 22 partially acclimatized lowlanders at 4,300 m (Cerro de Pasco, Peru) received an IV infusion of either 200 mg of iron (III)-hydroxide sucrose or saline. Markers of iron status were collected at baseline and 4 h after infusion. Echocardiography was performed in participants during room air breathing (partial pressure of inspired oxygen [PIO(2)] of approximately 96 mm Hg) and during exaggerated hypoxia (PIO(2) of approximately 73 mm Hg) at baseline and at 2 and 4 h after the infusion. RESULTS: Iron infusion reduced pulmonary artery systolic pressure (PASP) by approximately 2.5 mm Hg in room air (main effect, P < .001) and by approximately 7 mm Hg during exaggerated hypoxia (main effect, P < .001) in both lowlanders and healthy Andean highlanders. There was no change in PASP after the infusion of saline. Iron metrics were comparable between groups, except for serum ferritin, which was 1.8-fold higher at baseline in the Andeans than in the lowlanders (95% CI, 74-121 ng/mL vs 37-70 ng/mL, respectively; P = .003). INTERPRETATION: The pulmonary vasculature of healthy Andeans and lowlanders remains sensitive to iron infusion, and this response seems to differ from the pathologic characteristics of CMS en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Chest
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject high altitude en_US
dc.subject iron en_US
dc.subject Andean en_US
dc.subject pulmonary vasculature en_US
dc.title Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.chest.2021.08.075
dc.relation.issn 1931-3543


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