Universidad Peruana Cayetano Heredia

Risk Factors for Maternal Chagas Disease and Vertical Transmission in a Bolivian Hospital.

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dc.contributor.author Klein, Melissa D.
dc.contributor.author Tinajeros, Freddy
dc.contributor.author Del Carmen Menduiña, María
dc.contributor.author Málaga, Edith
dc.contributor.author Condori, Beth J.
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Urquizu, Federico
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Bowman, Natalie M.
dc.date.accessioned 2022-02-01T21:18:28Z
dc.date.available 2022-02-01T21:18:28Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11305
dc.description.abstract BACKGROUND: Vertical transmission of Trypanosoma cruzi infection accounts for a growing proportion of new cases of Chagas disease. Better risk stratification is needed to predict which women are more likely to transmit the infection. METHODS: This study enrolled women and their infants at the Percy Boland Women's Hospital in Santa Cruz, Bolivia. Pregnant women were screened for Chagas disease by rapid test and received confirmatory serology. Infants of seropositive mothers underwent diagnostic testing with quantitative polymerase chain reaction (qPCR). RESULTS: Among 5828 enrolled women, 1271 (21.8%) screened positive for Chagas disease. Older maternal age, family history of Chagas disease, home conditions, lower educational level, and history of living in a rural area were significantly associated with higher adjusted odds of maternal infection. Of the 1325 infants of seropositive mothers, 65 infants (4.9%) were diagnosed with congenital Chagas disease. Protective factors against transmission included cesarean delivery (adjusted odds ratio [aOR]: .60; 95% confidence interval [CI]: .36-.99) and family history of Chagas disease (aOR: .58; 95% CI: .34-.99). Twins were significantly more likely to be congenitally infected than singleton births (OR: 3.32; 95% CI: 1.60-6.90). Among congenitally infected infants, 32.3% had low birth weight, and 30.8% required hospitalization after birth. CONCLUSIONS: Although improved access to screening and qPCR increased the number of infants diagnosed with congenital Chagas disease, many infants remain undiagnosed. A better understanding of risk factors and improved access to highly sensitive and specific diagnostic techniques for congenital Chagas disease may help improve regional initiatives to reduce disease burden en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Pregnancy en_US
dc.subject Risk Factors en_US
dc.subject Infant en_US
dc.subject Mothers en_US
dc.subject *congenital Chagas disease en_US
dc.subject *Trypanosoma cruzi en_US
dc.subject Infectious Disease Transmission, Vertical en_US
dc.subject Hospitals en_US
dc.subject *vertical transmission en_US
dc.subject *risk factors en_US
dc.subject Bolivia/epidemiology en_US
dc.subject *Chagas disease en_US
dc.subject *Chagas Disease/diagnosis/epidemiology en_US
dc.title Risk Factors for Maternal Chagas Disease and Vertical Transmission in a Bolivian Hospital. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/cid/ciaa1885
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


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