Universidad Peruana Cayetano Heredia

A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru.

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dc.contributor.author Shrestha, Amber
dc.contributor.author Picoy, Janeth
dc.contributor.author Torres, Arturo
dc.contributor.author Moore, David Alexander James
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Coronel, Jorge
dc.contributor.author Grandjean, Louis
dc.date.accessioned 2022-02-01T21:18:28Z
dc.date.available 2022-02-01T21:18:28Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11321
dc.description.abstract BACKGROUND: The Tuberculosis (TB) burden in Peru is significant with respect to both disease morbidity and mortality. Furthermore the recent diversification of farming enterprise to include a wide range of animal species has necessitated the consideration of members of the Mycobacterium Tuberculosis Complex (MTBC) with the potential for zoonotic transmission. M. bovis and M. caprae, a lesser known member of the MTBC exhibit an exceptionally wide host spectrum in animals and are capable of causing disease in humans. M. bovis has a predictable resistance profile which includes resistance to pyrazinamide. Thus, failure to identify M. bovis as the causative agent in reported TB cases leads to higher levels of treatment failure and contributes to the transmission of drug-resistant TB. CASE PRESENTATION: Reported here are the clinical presentations, investigations and treatment histories of two patients identified from a population level genotyping study in Lima, Peru that were at the time of treatment thought to be M. tuberculosis patients but in retrospect were spectated using whole genome sequencing as M. caprae and M. Bovis. CONCLUSIONS: The cases reported here constitute convincing evidence that M. caprae and M. bovis are causative agents of TB infection in humans in Peru and underscore the importance of species-level MTBC member identification to effectively control and treat zoonotic TB. Furthermore these cases highlight the challenges of using clinical risk factors to identify cases of zoonotic TB in humans as their clinical presentation and transmission history is often difficult to distinguish from anthroponotic TB en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Peru/epidemiology en_US
dc.subject Bovis en_US
dc.subject Caprae en_US
dc.subject Case report en_US
dc.subject Zoonotic disease en_US
dc.subject Whole Genome Sequencing en_US
dc.subject *Mycobacterium tuberculosis/genetics en_US
dc.subject *Mycobacterium bovis/genetics en_US
dc.title A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12879-021-06944-5
dc.relation.issn 1471-2334


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