Universidad Peruana Cayetano Heredia

Applying the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Lupus Criteria to Patients From the LUMINA Cohort: Results From the Multiethnic, Multicenter US Cohort.

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dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Pons-Estel, Guillermo J.
dc.contributor.author Harvey, Guillermina B.
dc.contributor.author Vilá, Luis M.
dc.contributor.author Griffin, Russell
dc.contributor.author Alarcón, Graciela S.
dc.date.accessioned 2022-02-01T21:18:29Z
dc.date.available 2022-02-01T21:18:29Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11333
dc.description.abstract OBJECTIVE: To evaluate the performance of the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria for systemic lupus erythematosus (SLE) in terms of earlier SLE classification in comparison to the ACR or the Systemic Lupus International Collaborating Clinics (SLICC) criteria. METHODS: Patients from a multiethnic, multicenter cohort, the Lupus in Minorities: Nature versus Nurture cohort, where SLE was defined using the 1982/1997 ACR criteria were included. Demographic, clinical, and immunologic criteria were compared among the 2019 EULAR/ACR and the 1982/1997 ACR and the 2012 SLICC timing categories. RESULTS: The 2019 EULAR/ACR criteria allowed an earlier SLE classification in 13.3% of patients (mean 0.66 years) and 15.3% of patients (mean 0.63 years) compared to the 1982/1997 ACR and the 2012 SLICC criteria, respectively. Patients accruing the 2019 EULAR/ACR criteria later than the 1982/1997 ACR criteria had a lower disease activity, were less likely to have positivity to anti-double-stranded DNA and anti-Sm, as well as lupus nephritis classes II or V; they were more likely to have mucocutaneous manifestations, serositis, leukopenia, and antiphospholipid antibodies positivity. These differences were less pronounced when compared to the 2012 SLICC criteria CONCLUSION: The 2019 EULAR/ACR criteria classified SLE patients earlier than the 2 other criteria sets in real-life clinical practice scenarios in a relatively small proportion of the patients. However, these criteria could allow earlier classification of a subset of patients with a more severe disease en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Arthritis Care and Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Adult en_US
dc.subject Young Adult en_US
dc.subject *Rheumatology en_US
dc.subject Severity of Illness Index en_US
dc.subject Databases, Factual en_US
dc.subject Reproducibility of Results en_US
dc.subject Early Diagnosis en_US
dc.subject Predictive Value of Tests en_US
dc.subject United States/epidemiology en_US
dc.subject *Minority Health en_US
dc.subject Societies, Medical en_US
dc.subject *Minority Groups en_US
dc.subject Lupus Erythematosus, Systemic/classification/*diagnosis/ethnology/immunology en_US
dc.subject Race Factors en_US
dc.title Applying the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Lupus Criteria to Patients From the LUMINA Cohort: Results From the Multiethnic, Multicenter US Cohort. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/acr.24367
dc.relation.issn 2151-4658


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