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dc.contributor.author | Bernabé Ortiz, Antonio | |
dc.contributor.author | Carrillo Larco, Rodrigo Martín | |
dc.contributor.author | Gilman, Robert Hugh | |
dc.contributor.author | Smeeth, Liam | |
dc.contributor.author | Checkley, William | |
dc.contributor.author | Miranda, J. Jaime | |
dc.date.accessioned | 2022-02-17T19:23:11Z | |
dc.date.available | 2022-02-17T19:23:11Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/11366 | |
dc.description.abstract | Purpose: To assess the association between all-cause mortality and hs-CRP, based mainly on the cumulative burden approach. Methods: Cohort study with adults ≥35 years from general population, using hs-CRP at two timepoints: at baseline and 30 months later to establish different exposures: change over time, cumulative, and weighted cumulative hs-CRP. The outcome was all-cause mortality assessed 7 years later. Cox models were generated to quantify the association. Results: Data from 3,119 participants (mean age 55.6 years, and 51.2% females), were analyzed. During follow-up, 164 (5.6%) deaths occurred over 20,314.5 person-years, indicating an overall mortality rate of 8.1 per 1,000 person-years. In multivariable model, hs-CRP at baseline was associated with high risk of mortality (HR = 1.77; 95%CI: 1.28–2.46). Similarly, hs-CRP change over time (HR = 2.50; 95%CI: 1.46–4.29), as well as cumulative and weighted cumulative hs-CRP (HR = 2.05; 95%CI: 1.31–3.20) were associated with greater risk of all-cause mortality. The weighted cumulative hs-CRP had the best goodness-of-fit for mortality prediction. Conclusions: In this cohort across diverse geographical low-resource settings, high levels of hs-CRP were strongly associated with all-cause mortality. Two measurements of hs-CRP are better than one to predict mortality, and the weighted cumulative approach had the best prognostic fit. | en_US |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Annals of Epidemiology | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Mortality | en_US |
dc.subject | Inflammation | en_US |
dc.subject | C-reactive protein | en_US |
dc.subject | Cohort Studies | en_US |
dc.subject | Peru | en_US |
dc.title | High-sensitivity C-reactive protein and all-cause mortality in four diverse populations: The CRONICAS Cohort Study | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1016/j.annepidem.2021.12.007 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.09 | |
dc.relation.issn | 1873-2585 |
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