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Advances in the treatment, diagnosis, control and scientific understanding of taeniid cestode parasite infections over the past 50 years

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dc.contributor.author Lightowlers, Marshall W.
dc.contributor.author Gasser, Robin B.
dc.contributor.author Hemphill, Andrew
dc.contributor.author Romig, Thomas
dc.contributor.author Tamarozzi, Francesca
dc.contributor.author Deplazes, Peter
dc.contributor.author Torgerson, Paul R.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Kern, Peter
dc.date.accessioned 2022-02-17T19:23:12Z
dc.date.available 2022-02-17T19:23:12Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/11378
dc.description.abstract In the past 50 years, enormous progress has been made in the diagnosis, treatment and control of taeniid cestode infections/diseases and in the scientific understanding thereof. Most interest in this group of parasites stems from the serious diseases that they cause in humans. It is through this lens that we summarize here the most important breakthroughs that have made a difference to the treatment of human diseases caused by these parasites, reduction in transmission of the taeniid species associated with human disease, or understanding of the parasites’ biology likely to impact diagnosis or treatment in the foreseeable future. Key topics discussed are the introduction of anti-cestode drugs, including benzimidazoles and praziquantel, and the development of new imaging modalities that have transformed the diagnosis and post-treatment monitoring of human echinococcoses and neurocysticercosis. The availability of new anti-cestode drugs for use in dogs and a detailed understanding of the transmission dynamics of Echinococcus granulosus sensu lato have underpinned successful programs that have eliminated cystic echinococcosis in some areas of the world and greatly reduced the incidence of infection in others. Despite these successes, cystic and alveolar echinococcosis and neurocysticercosis continue to be prevalent in many parts of the world, requiring new or renewed efforts to prevent the associated taeniid infections. Major advances made in the development of practical vaccines against E. granulosus and Taenia solium will hopefully assist in this endeavour, as might the understanding of the parasites’ biology that have come from an elucidation of the nuclear genomes of each of the most important taeniid species causing human diseases. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal for Parasitology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Taeniid cestode en_US
dc.subject EchinococcusTaenia en_US
dc.subject Benzimidazoles en_US
dc.subject Praziquantel en_US
dc.subject Imaging en_US
dc.subject Genome en_US
dc.subject Transmission dynamics en_US
dc.subject Vaccine and control en_US
dc.title Advances in the treatment, diagnosis, control and scientific understanding of taeniid cestode parasite infections over the past 50 years en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1016/j.ijpara.2021.10.003
dc.relation.issn 1879-0135


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