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LLDAS (lupus low disease activity state) and/or remission are associated with less damage accrual in patients with systemic lupus erythematosus from a primarily Mestizo population: Data from the Almenara Lupus Cohort

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dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Gamboa-Cardenas, Rocio Violeta
dc.contributor.author Reategui-Sokolova, Cristina
dc.contributor.author Pimentel Quiroz, Víctor Roman
dc.contributor.author Medina, Mariela
dc.contributor.author Elera-Fitzcarrald, Claudia
dc.contributor.author Zevallos, Francisco
dc.contributor.author Pastor-Asurza, Cesar Augusto
dc.contributor.author Lofland, Jeniffer
dc.contributor.author Zazzetti, Federico
dc.contributor.author Karyekar, Chetan S.
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Perich-Campos, Risto Alfredo
dc.date.accessioned 2022-03-23T16:54:21Z
dc.date.available 2022-03-23T16:54:21Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11483
dc.description.abstract Objective To determine if achieving lupus low disease activity state (LLDAS) or remission prevents damage accrual in a primarily Mestizo population. Methods Patients with SLE from a single-centre cohort with at least two visits occurring every 6 months were included. The definitions used were the following: for remission, the 2021 Definition Of Remission In SLE; and for LLDAS, the Asia Pacific Lupus Collaboration. Damage accrual was ascertained with the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Univariable and three multivariable interval-censored survival regression models were done: (1) remission versus not on remission; (2) LLDAS/remission versus active; and (3) remission and LLDAS (not on remission) versus active. Three similar multivariable models were also examined considering the duration on each state. Possible confounders included in these analyses were gender, age at diagnosis, socioeconomic status, educational level, disease duration, antimalarial use and SDI at baseline. Results Two hundred and eighty-one patients were included. Eighty-three patients (29.5%) showed increased SDI during the follow-up. In the analyses of remission, being on remission predicted a lower probability of damage (HR=0.456; 95% CI 0.256 to 0.826; p=0.010). In the analyses of LLDAS/remission, being on LLDAS/remission predicted a lower damage (HR=0.503; 95% CI 0.260 to 0.975; p=0.042). When both states were considered, remission but not LLDAS (not on remission) predicted a lower probability of damage (HR=0.423; 95% CI 0.212 to 0.846; p=0.015 and HR=0.878; 95% CI 0.369 to 2.087; p=0.768, respectively). When the duration of these states was taken into account, remission, LLDAS/remission and LLDAS not on remission were associated with a lower probability of damage accrual. Conclusions LLDAS and/or remission were associated with a lower probability of damage accrual. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Lupus Science and Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject systemic lupus erythematosus en_US
dc.subject therapeutics en_US
dc.subject outcome assessment, health care en_US
dc.title LLDAS (lupus low disease activity state) and/or remission are associated with less damage accrual in patients with systemic lupus erythematosus from a primarily Mestizo population: Data from the Almenara Lupus Cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/lupus-2021-000616
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 2053-8790


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