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Pharmacogenetics research in Brazil: a systematic review.

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dc.contributor.author Torres-Loureiro, Sabrina
dc.contributor.author Scudeler, Mariana M.
dc.contributor.author Andrade, Poliana Xc
dc.contributor.author Sampaio-Coelho, Julia
dc.contributor.author Nobre, Igor H.
dc.contributor.author Céspedes-Garro, Carolina
dc.contributor.author Tarazona-Santos, Eduardo
dc.contributor.author Llerena, Adrián
dc.contributor.author Rodrigues-Soares, Fernanda
dc.date.accessioned 2022-03-23T16:54:21Z
dc.date.available 2022-03-23T16:54:21Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11490
dc.description.abstract Aim: Pharmacogenomics (PGx) is a rising scientific area in many countries, such as Brazil. Objectives: To identify biomarkers, therapeutic areas, probe drugs and regions/ethnicities most studied in the country in order to guide future studies. Materials & methods: Systematic review of 1060 studies (from 1968 to 2020) comprising 80 genes, six probe drugs and 3,819,233 individuals. Results: MTHFR and HLA-A/B were the most studied genes and metoprolol and dextromethorphan the most studied probe drugs. Oncology was the most studied therapeutic area considering PGx biomarkers. The country's regions and ethnic groups were studied unevenly, with south/southeast and White people over-represented in respect to their demographic relevance, in detriment of the center-west/northeast/north and Black/mixed individuals. Conclusion: Many of the gaps and possible paths to be covered to reach even PGx data are pointed out by this review. en_US
dc.language.iso eng
dc.publisher Future Medicine
dc.relation.ispartofseries Pharmacogenomics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Brazil en_US
dc.subject population genetics en_US
dc.subject pharmacogenetics en_US
dc.title Pharmacogenetics research in Brazil: a systematic review. en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.2217/pgs-2021-0128
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1744-8042


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