DSpace Repository

Weight gain post-ART in HIV+ Latinos/as differs in the USA, Haiti, and Latin America

Show simple item record

dc.contributor.author Coelho, Lara E.
dc.contributor.author Jenkins, Cathy A.
dc.contributor.author Shepherd, Bryan E.
dc.contributor.author Pape, Jean W.
dc.contributor.author Mejía Cordero, Fernando
dc.contributor.author Padgett, Denis
dc.contributor.author Crabtree Ramirez, Brenda
dc.contributor.author Grinsztejn, Beatriz
dc.contributor.author Althoff, Keri N.
dc.contributor.author Koethe, John R.
dc.contributor.author Marconi, Vicent C.
dc.contributor.author Tien, Phyllis C.
dc.contributor.author Willig, Amanda L.
dc.contributor.author Moore, Richard D.
dc.contributor.author Castilho, Jessica L.
dc.contributor.author Colasanti, Jonathan
dc.contributor.author Crane, Heidi M.
dc.contributor.author Gill, M.John
dc.contributor.author Horberg, Michael A.
dc.contributor.author Mayor, Angel
dc.contributor.author Silverberg, Michael J.
dc.contributor.author McGowan, Catherine
dc.contributor.author Rebeiro, Peter F.
dc.date.accessioned 2022-04-26T17:26:49Z
dc.date.available 2022-04-26T17:26:49Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11596
dc.description.abstract Background: An obesity epidemic has been documented among adult Latinos/as in Latin America and the United States (US); however, little is known about obesity among Latinos/as with HIV (PWH). Moreover, Latinos/as PWH in the US may have different weight trajectories than those in Latin America due to the cultural and environmental contexts. We assessed weight and body mass index (BMI) trajectories among PWH initiating antiretroviral therapy (ART) across 5 countries in Latin America and the Caribbean and the US. Methods: ART-naïve PWH ≥18 years old, enrolled in Brazil, Honduras, Mexico, Peru, and Haiti (sites within CCASAnet) and the US (NA-ACCORD) starting ART between 2000 and 2017, with at least one weight measured after ART initiation were included. Participants were classified according to site/ethnicity as: Latinos/as in US, non-Latinos/as in US, Haitians, and Latinos/as in Latin America. Generalized least squares models were used to assess trends in weight and BMI. Models estimating probabilities of becoming overweight/obese (BMI ≥25 kg/m²) and of becoming obese (BMI ≥30 kg/m²) post ART initiation for males and females were fit using generalized estimating equations with a logit link and an independence working correlation structure. Findings: Among 59,207 PWH, 9% were Latinos/as from Latin America, 9% Latinos/as from the US, 68% non-Latinos/as from the US and 14% were Haitian. At ART initiation, 29% were overweight and 14% were obese. Post-ART weight and BMI increases were steeper for Latinos/as in Latin America compared with other sites/ethnicities; however, BMI at 3-years post ART remained lower compared to Latinos/as and non-Latinos/as in the US. Among females, at 3-years post ART initiation the greatest adjusted probability of obesity was found among non-Latinas in the US (15·2%) and lowest among Latinas in Latin America (8·6%). Among males, while starting with a lower BMI, Latinos in Latin America had the greatest adjusted probability of becoming overweight or obese 3-years post-ART initiation. Interpretation: In the Americas, PWH gain substantial weight after ART initiation. Despite environmental and cultural differences, PWH in Latin America, Haiti and Latinos and non-Latinos in the US share similar BMI trajectories on ART and high probabilities of becoming overweight and obese over time. Multicohort studies are needed to better understand the burden of other metabolic syndrome components in PWH across different countries. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Lancet Regional Health. Americas
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Latin America en_US
dc.subject Obesity en_US
dc.subject HIV en_US
dc.subject Ethnicity en_US
dc.subject Weight gain en_US
dc.subject Antiretroviral en_US
dc.title Weight gain post-ART in HIV+ Latinos/as differs in the USA, Haiti, and Latin America en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.lana.2021.100173
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 2667-193X


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics