Universidad Peruana Cayetano Heredia

Development of a dose-response model for porcine cysticercosis

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dc.contributor.author Andrade-Mogrovejo, Daniel A.
dc.contributor.author Gonzales-Gustavson, Eloy
dc.contributor.author Ho-Palma, Ana C.
dc.contributor.author Prada, Joaquin M.
dc.contributor.author Bonnet, Gabrielle
dc.contributor.author Pizzitutti, Francesco
dc.contributor.author Gomez-Puerta, Luis A.
dc.contributor.author Arroyo Hurtado, Gianfranco
dc.contributor.author O'Neal, Seth E.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Guitian, Javier
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.date.accessioned 2022-04-26T17:26:49Z
dc.date.available 2022-04-26T17:26:49Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11607
dc.description.abstract Taenia solium is an important cause of acquired epilepsy worldwide and remains endemic in Asia, Africa, and Latin America. Transmission of this parasite is still poorly understood despite the design of infection experiments to improve our knowledge of the disease, with estimates for critical epidemiological parameters, such as the probability of human-to-pig infection after exposure to eggs, still lacking. In this paper, a systematic review was carried out and eight pig infection experiments were analyzed to describe the probability of developing cysts. These experiments included different pathways of inoculation: with ingestion of proglottids, eggs, and beetles that ingested eggs, and direct injection of activated oncospheres into the carotid artery. In these experiments, different infective doses were used, and the numbers of viable and degenerated cysts in the body and brain of each pig were registered. Five alternative dose-response models (exponential, logistic, log-logistic, and exact and approximate beta-Poisson) were assessed for their accuracy in describing the observed probabilities of cyst development as a function of the inoculation dose. Doseresponse models were developed separately for the presence of three types of cysts (any, viable only, and cysts in the brain) and considered for each of the four inoculation methods ("Proglottids", "Eggs", "Beetles"and "Carotid"). The exact beta-Poisson model best fit the data for the three types of cysts and all relevant exposure pathways. However, observations for some exposure pathways were too scarce to reliably define a dose-response curve with any model. A wide enough range of doses and sufficient sample sizes was only found for the "Eggs"pathway and a merged "Oral"pathway combining the "Proglottids", "Eggs"and "Beetles"pathways. Estimated parameter values from this model suggest that a low infective dose is sufficient to result in a 50% probability for the development of any cyst or for viable cyst infections. Although this is a preliminary model reliant on a limited dataset, the parameters described in this manuscript should contribute to the design of future experimental infections related to T. solium transmission, as well as the parameterization of simulation models of transmission aimed at informing control. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Eggs en_US
dc.subject Swine en_US
dc.subject Beetles en_US
dc.subject Cysticercosis en_US
dc.subject Ingestion en_US
dc.subject Parasitic diseases en_US
dc.subject Pig models en_US
dc.subject Database searching en_US
dc.title Development of a dose-response model for porcine cysticercosis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1371/journal.pone.0264898
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1932-6203


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