Universidad Peruana Cayetano Heredia

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium

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dc.contributor.author Fernández-Rhodes, L.
dc.contributor.author Graff, M.
dc.contributor.author Buchanan, V.L.
dc.contributor.author Justice, A.E.
dc.contributor.author Highland, H.M.
dc.contributor.author Guo, X.
dc.contributor.author Zhu, W.
dc.contributor.author Chen, H.-H.
dc.contributor.author Young, K.L.
dc.contributor.author Adhikari, K.
dc.contributor.author Palmer, N.D.
dc.contributor.author Below, J.E.
dc.contributor.author Bradfield, J.
dc.contributor.author Pereira, A.C.
dc.contributor.author Glover, L.S.
dc.contributor.author Kim, D.
dc.contributor.author Lilly, A.G.
dc.contributor.author Shrestha, P.
dc.contributor.author Thomas, A.G.
dc.contributor.author Zhang, X.
dc.contributor.author Chen, M.
dc.contributor.author Chiang, C.W.K.
dc.contributor.author Pulit, S.
dc.contributor.author Horimoto, A.
dc.contributor.author Krieger, J.E.
dc.contributor.author Guindo-Martínez, M.
dc.contributor.author Preuss, M.
dc.contributor.author Schumann, C.
dc.contributor.author Smit, R.A.J.
dc.contributor.author Torres-Mejía, G.
dc.contributor.author Acuña-Alonzo, V.
dc.contributor.author Bedoya, G.
dc.contributor.author Bortolini, M.-C.
dc.contributor.author Canizales-Quinteros, S.
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author González-José, R.
dc.contributor.author Poletti, G.
dc.contributor.author Rothhammer, F.
dc.contributor.author Hakonarson, H.
dc.contributor.author Igo, R.
dc.contributor.author Adler, S.G.
dc.contributor.author Iyengar, S.K.
dc.contributor.author Nicholas, S.B.
dc.contributor.author Gogarten, S.M.
dc.contributor.author Isasi, C.R.
dc.contributor.author Papnicolaou, G.
dc.contributor.author Stilp, A.M.
dc.contributor.author Qi, Q.
dc.contributor.author Kho, M.
dc.contributor.author Smith, J.A.
dc.contributor.author Langefeld, C.D.
dc.contributor.author Wagenknecht, L.
dc.contributor.author Mckean-Cowdin, R.
dc.contributor.author Gao, X.R.
dc.contributor.author Nousome, D.
dc.contributor.author Conti, D.V.
dc.contributor.author Feng, Y.
dc.contributor.author Allison, M.A.
dc.contributor.author Arzumanyan, Z.
dc.contributor.author Buchanan, T.A.
dc.contributor.author Ida Chen, Y.-D.
dc.contributor.author Genter, P.M.
dc.contributor.author Goodarzi, M.O.
dc.contributor.author Hai, Y.
dc.contributor.author Hsueh, W.
dc.contributor.author Ipp, E.
dc.contributor.author Kandeel, F.R.
dc.contributor.author Lam, K.
dc.contributor.author Li, X.
dc.contributor.author Nadler, J.L.
dc.contributor.author Raffel, L.J.
dc.contributor.author Roll, K.
dc.contributor.author Sandow, K.
dc.contributor.author Tan, J.
dc.contributor.author Taylor, K.D.
dc.contributor.author Xiang, A.H.
dc.contributor.author Yao, J.
dc.contributor.author Audirac-Chalifour, A.
dc.contributor.author de Jesus Peralta Romero, J.
dc.contributor.author Hartwig, F.
dc.contributor.author Horta, B.
dc.contributor.author Blangero, J.
dc.contributor.author Curran, J.E.
dc.contributor.author Duggirala, R.
dc.contributor.author Lehman, D.E.
dc.contributor.author Puppala, S.
dc.contributor.author Fejerman, L.
dc.contributor.author John, E.M.
dc.contributor.author Aguilar-Salinas, C.
dc.contributor.author Burtt, N.P.
dc.contributor.author Florez, J.C.
dc.contributor.author García-Ortíz, H.
dc.contributor.author González-Villalpando, C.
dc.contributor.author Mercader, J.
dc.contributor.author Orozco, L.
dc.contributor.author Tusié-Luna, T.
dc.contributor.author Blanco, E.
dc.contributor.author Gahagan, S.
dc.contributor.author Cox, N.J.
dc.contributor.author Hanis, C.
dc.contributor.author Butte, N.F.
dc.contributor.author Cole, S.A.
dc.contributor.author Comuzzie, A.G.
dc.contributor.author Voruganti, V.S.
dc.contributor.author Rohde, R.
dc.contributor.author Wang, Y.
dc.contributor.author Sofer, T.
dc.contributor.author Ziv, E.
dc.contributor.author Grant, S.F.A.
dc.contributor.author Ruiz-Linares, A.
dc.contributor.author Rotter, J.I.
dc.contributor.author Haiman, C.A.
dc.contributor.author Parra, E.J.
dc.contributor.author Cruz, M.
dc.contributor.author Loos, R.J.F.
dc.contributor.author North, K.E.
dc.date.accessioned 2022-06-01T13:53:56Z
dc.date.available 2022-06-01T13:53:56Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11726
dc.description.abstract Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries HGG advances
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject obesity en_US
dc.subject diversity en_US
dc.subject anthropometrics en_US
dc.subject fine-mapping en_US
dc.subject Hispanic/Latino en_US
dc.subject population stratification en_US
dc.subject trans-ancestral or trans-ethnic en_US
dc.title Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.xhgg.2022.100099
dc.relation.issn 2666-2477


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