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A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV

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dc.contributor.author Ndlangisa, K.M.
dc.contributor.author du Plessis, M.
dc.contributor.author Lo, S.
dc.contributor.author de Gouveia, L.
dc.contributor.author Chaguza, C.
dc.contributor.author Antonio, M.
dc.contributor.author Kwambana-Adams, B.
dc.contributor.author Cornick, J.
dc.contributor.author Everett, D.B.
dc.contributor.author Dagan, R.
dc.contributor.author Hawkins, P.A.
dc.contributor.author Beall, B.
dc.contributor.author Corso, A.
dc.contributor.author Grassi Almeida, S.C.
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Obaro, S.
dc.contributor.author Shakoor, S.
dc.contributor.author Donkor, E.S.
dc.contributor.author Gladstone, R.A.
dc.contributor.author Ho, P.L.
dc.contributor.author Paragi, M.
dc.contributor.author Doiphode, S.
dc.contributor.author Srifuengfung, S.
dc.contributor.author Ford, R.
dc.contributor.author Moïsi, J.
dc.contributor.author Saha, S.K.
dc.contributor.author Bigogo, G.
dc.contributor.author Sigauque, B.
dc.contributor.author Eser, ÖK.
dc.contributor.author Elmdaghri, N.
dc.contributor.author Titov, L.
dc.contributor.author Turner, P.
dc.contributor.author Kumar, K.L.R.
dc.contributor.author Kandasamy, R.
dc.contributor.author Egorova, E.
dc.contributor.author Ip, M.
dc.contributor.author Breiman, R.F.
dc.contributor.author Klugman, K.P.
dc.contributor.author McGee, L.
dc.contributor.author Bentley, S.D.
dc.contributor.author von Gottberg, A.
dc.contributor.author The Global Pneumococcal Sequencing Consortium
dc.date.accessioned 2022-06-01T13:53:57Z
dc.date.available 2022-06-01T13:53:57Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11747
dc.description.abstract Pneumococcal serotype 35B is an important non-conjugate vaccine (non-PCV) serotype. Its continued emergence, post-PCV7 in the USA, was associated with expansion of a pre-existing 35B clone (clonal complex [CC] 558) along with post-PCV13 emergence of a non-35B clone previously associated with PCV serotypes (CC156). This study describes lineages circulating among 35B isolates in South Africa before and after PCV introduction. We also compared 35B isolates belonging to a predominant 35B lineage in South Africa (GPSC5), with isolates belonging to the same lineage in other parts of the world. Serotype 35B isolates that caused invasive pneumococcal disease in South Africa in 2005-2014 were characterized by whole-genome sequencing (WGS). Multi-locus sequence types and global pneumococcal sequence clusters (GPSCs) were derived from WGS data of 63 35B isolates obtained in 2005-2014. A total of 262 isolates that belong to GPSC5 (115 isolates from South Africa and 147 from other countries) that were sequenced as part of the global pneumococcal sequencing (GPS) project were included for comparison. Serotype 35B isolates from South Africa were differentiated into seven GPSCs and GPSC5 was most common (49 %, 31/63). While 35B was the most common serotype among GPSC5/CC172 isolates in South Africa during the PCV13 period (66 %, 29/44), 23F was the most common serotype during both the pre-PCV (80 %, 37/46) and PCV7 period (32 %, 8/25). Serotype 35B represented 15 % (40/262) of GPSC5 isolates within the global GPS database and 75 % (31/40) were from South Africa. The predominance of the GPSC5 lineage within non-vaccine serotype 35B, is possibly unique to South Africa and warrants further molecular surveillance of pneumococci. en_US
dc.language.iso eng
dc.publisher Microbiology Society
dc.relation.ispartofseries Microbial Genomics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Streptococcus pneumoniae en_US
dc.subject South Africa en_US
dc.subject global pneumococcal sequence cluster en_US
dc.subject serotype 35B en_US
dc.title A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1099/mgen.0.000746
dc.relation.issn 2057-5858


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